DEPTOR anticorps (AA 111-301)

N° du produit ABIN5027150

Détail du produit anti-DEPTOR anticorps

Antigène: DEPTOR (DEP Domain Containing mTOR-Interacting Protein (DEPTOR))

Épitope: AA 111-301

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DEPTOR est non-conjugé

Application: Western Blotting (WB)

Purification: Protein A Chromatography

Immunogène: A partial length recombinant DEPTOR protein (amino acids 111-301) was used as the immunogen for this antibody.

Isotype: IgG

Information d'application

Indications d'application: WB: 2-4 μg/mL

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: PBS containing 0.05 % BSA, PH 7.4

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Détails sur DEPTOR

Antigène: DEPTOR (DEP Domain Containing mTOR-Interacting Protein (DEPTOR))

Autre désignation: DEPTOR/DEPDC6 (DEPTOR Produits)

Synonymes: anticorps DEP.6, anticorps DEPDC6, anticorps 4731402B04Rik, anticorps 9130412E02Rik, anticorps D15Ertd336e, anticorps D15Ertd597e, anticorps Depdc6, anticorps Depdc6-001, anticorps Depdc6-002, anticorps R75183, anticorps mKIAA4200, anticorps RGD1561030, anticorps RAPGEF4, anticorps DEP domain containing MTOR interacting protein, anticorps DEP domain containing MTOR-interacting protein, anticorps DEPTOR, anticorps Deptor

Sujet: DEPTOR is an mTOR inhibitor whose expression is negatively regulated by mTOR. DEPTOR expression is required to maintain PI3K and Akt activation and to inhibit apoptosis. DEPTOR is expressed in different microvascular ECs (endothelial cells). It plays a key role in maintaining stem cell pluripotency by limiting mTOR activity in undifferentiated embryonic stem cells (ESCs). It is overexpressed in RPMI-8226 human multiple myeloma cells, and plays an important role in maintaining cell survival.

Poids moléculaire: 46 kDa

ID gène: 64798

UniProt: Q8TB45

Pathways: Signalisation PI3K-Akt, Signalisation RTK, Regulation of Cell Size, BCR Signaling, L'effet Warburg