Desmocollin 3 anticorps (Middle Region)

N° du produit ABIN5514719

Détail du produit anti-Desmocollin 3 anticorps

Antigène: Desmocollin 3 (DSC3)

Épitope: Middle Region

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Desmocollin 3 est non-conjugé

Application: Western Blotting (WB)

Séquence: IKENLAVGSK INGYKAYDPE NRNGNGLRYK KLHDPKGWIT IDEISGSIIT

Purification: Affinity purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human DSC3

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur Desmocollin 3

Antigène: Desmocollin 3 (DSC3)

Autre désignation: DSC3 (DSC3 Produits)

Synonymes: anticorps CDHF3, anticorps DSC, anticorps DSC1, anticorps DSC2, anticorps DSC4, anticorps HT-CP, anticorps 5430426I24Rik, anticorps MGC85083, anticorps desmocollin 3, anticorps desmocollin 3 S homeolog, anticorps DSC3, anticorps Dsc3, anticorps dsc3.S, anticorps dsc3

Sujet: The protein encoded by this gene is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. The desmosomal family members are arranged in two clusters on chromosome 18, occupying less than 650 kb combined. Mutations in this gene are a cause of hypotrichosis and recurrent skin vesicles disorder. The protein can act as an autoantigen in pemphigus diseases, and it is also considered to be a biomarker for some cancers. Alternative splicing of this gene results in multiple transcript variants.

Alias Symbols: DSC, DSC1, DSC2, DSC4, CDHF3, HT-CP,

Protein Size: 839

ID gène: 1825

NCBI Accession: NM_001941, NP_001932