WISP1 anticorps (N-Term)

N° du produit ABIN5515250

Cet anticorps anti-WISP1 est un anticorps Lapin Polyclonal détectant WISP1 dans WB. Adapté pour Humain.

Aperçu rapide pour WISP1 anticorps (N-Term) (ABIN5515250)

Antigène: WISP1 (WNT1 Inducible Signaling Pathway Protein 1 (WISP1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp WISP1 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-WISP1 anticorps

Épitope: N-Term

Séquence: RCPLGVSLIT DGCECCKMCA QQLGDNCTEA AICDPHRGLY CDYSGDRPRY

Homologie: Cow: 93%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 89%

Purification: Affinity purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human WISP1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur WISP1

Antigène: WISP1 (WNT1 Inducible Signaling Pathway Protein 1 (WISP1))

Autre désignation: WISP1

Sujet: This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like domain. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. It is expressed at a high level in fibroblast cells, and overexpressed in colon tumors. The encoded protein binds to decorin and biglycan, two members of a family of small leucine-rich proteoglycans present in the extracellular matrix of connective tissue, and possibly prevents the inhibitory activity of decorin and biglycan in tumor cell proliferation. It also attenuates p53-mediated apoptosis in response to DNA damage through activation of the Akt kinase. It is 83 % identical to the mouse protein at the amino acid level. Multiple alternatively spliced transcript variants have been identified.

Alias Symbols: CCN4, WISP1c, WISP1i, WISP1tc

Protein Interaction Partner: BGN, DCN, UGGT1,

Protein Size: 367

ID gène: 8840

NCBI Accession: NM_001204869, NP_003873

UniProt: O95388

Pathways: Signalisation WNT, Growth Factor Binding