CD11b anticorps (C-Term)

N° du produit ABIN5515864

L’anticorps anti-CD11b Polyclonal Lapin est utilisé pour la détection de CD11b dans des échantillons de Humain. Il a été validé pour WB.

Aperçu rapide pour CD11b anticorps (C-Term) (ABIN5515864)

Antigène: CD11b (ITGAM) (Integrin alpha M (ITGAM))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CD11b est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-CD11b anticorps

Épitope: C-Term

Fonction: ITGAM Antibody - C-terminal region

Séquence: PFEVPNPLPL IVGSSVGGLL LLALITAALY KLGFFKRQYK DMMSEGGPPG

Purification: Affinity purified

Immunogène: The immunogen is a synthetic peptide directed towards the C terminal region of human ITGAM

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP77901-100UG

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Détails sur CD11b

Antigène: CD11b (ITGAM) (Integrin alpha M (ITGAM))

Autre désignation: ITGAM

Sujet:

Background Information: This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene Name: integrin subunit alpha M

Alternative Symbols: CR3A, MO1A, CD11B, MAC-1, MAC1A, SLEB6

Protein Name: integrin alpha-M

Poids moléculaire: 126 kDa

ID gène: 3684

NCBI Accession: NP_000623

UniProt: P11215

Pathways: Apoptose, Activation of Innate immune Response, Toll-Like Receptors Cascades, Activated T Cell Proliferation