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SETD7 anticorps (N-Term)

SETD7 Reactivité: Humain, Souris, Rat, Chien, Cheval, Porc, Lapin, Boeuf (Vache), Poisson zèbre (Danio rerio), Cobaye WB Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN5517321
  • Antigène Voir toutes SETD7 Anticorps
    SETD7 (SET Domain Containing (Lysine Methyltransferase) 7 (SETD7))
    Épitope
    • 16
    • 7
    • 7
    • 4
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reactivité
    • 66
    • 18
    • 9
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    Humain, Souris, Rat, Chien, Cheval, Porc, Lapin, Boeuf (Vache), Poisson zèbre (Danio rerio), Cobaye
    Hôte
    • 55
    • 10
    • 1
    Lapin
    Clonalité
    • 52
    • 13
    • 1
    Polyclonal
    Conjugué
    • 33
    • 5
    • 4
    • 4
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp SETD7 est non-conjugé
    Application
    • 57
    • 29
    • 25
    • 17
    • 13
    • 13
    • 12
    • 11
    • 6
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    Western Blotting (WB)
    Séquence
    MDSDDEMVEE AVEGHLDDDG LPHGFCTVTY SSTDRFEGNF VHGEKNGRGK
    Homologie
    Cow: 93%, Dog: 93%, Guinea Pig: 86%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 92%
    Attributs du produit
    This is a rabbit polyclonal antibody against SETD7. It was validated on Western Blot.
    Purification
    Affinity purified
    Immunogène
    The immunogen is a synthetic peptide directed towards the N-terminal region of Human SETD7
    Top Product
    Discover our top product SETD7 Anticorps primaire
  • Indications d'application
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Antigène
    SETD7 (SET Domain Containing (Lysine Methyltransferase) 7 (SETD7))
    Autre désignation
    SETD7 (SETD7 Produits)
    Synonymes
    anticorps KMT7, anticorps SET7, anticorps SET7/9, anticorps SET9, anticorps set7, anticorps zgc:101860, anticorps zgc:92330, anticorps 1600028F23Rik, anticorps H3K4MT, anticorps Set7, anticorps Set7/9, anticorps mKIAA1717, anticorps SET domain containing lysine methyltransferase 7, anticorps SET domain containing (lysine methyltransferase) 7, anticorps SETD7, anticorps setd7, anticorps Setd7
    Sujet
    SETD7 is a histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. It plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation.

    Alias Symbols: SETD7, KIAA1717, KMT7, SET7, SET9,

    Protein Interaction Partner: KLF4, HIST3H3, SOX2, PRKAR1A, A1BG, TP53, NR2F2, STEAP3, SERTAD1, DPY30, MED1, MYOD1, E2F1, HIST1H3A, SMARCA4, H3F3A, STAT3, RELA, AR, UBC, DNMT1, PPP1R12A, SIRT1, TBP, TAF10, TAF7, TAF6, HIST1H4A, ESR1, HIST2H3C, HCFC1, L3MBTL1,

    Protein Size: 366
    ID gène
    80854
    NCBI Accession
    NP_085151
    UniProt
    Q8WTS6
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