SPAM1 anticorps (Middle Region)

N° du produit ABIN5517624

Détail du produit anti-SPAM1 anticorps

Antigène: SPAM1 (Sperm Adhesion Molecule 1 (PH-20 Hyaluronidase, Zona Pellucida Binding) (SPAM1))

Épitope: Middle Region

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SPAM1 est non-conjugé

Application: Western Blotting (WB)

Séquence: QQQNVQLSLT EATEKAKQEF EKAGKDFLVE TIKLGKLLRP NHLWGYYLFP

Attributs du produit: This is a rabbit polyclonal antibody against SPAM1. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of Human SPAM1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur SPAM1

Antigène: SPAM1 (Sperm Adhesion Molecule 1 (PH-20 Hyaluronidase, Zona Pellucida Binding) (SPAM1))

Autre désignation: SPAM1 (SPAM1 Produits)

Synonymes: anticorps AV039194, anticorps Ph-20, anticorps PH-20, anticorps PH20, anticorps HYA1, anticorps HYAL1, anticorps HYAL3, anticorps HYAL5, anticorps SPAG15, anticorps Spam, anticorps XEH1, anticorps spam1, anticorps im:6902904, anticorps zgc:158668, anticorps sperm adhesion molecule 1, anticorps sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding) L homeolog, anticorps sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding), anticorps Spam1, anticorps SPAM1, anticorps spam1.L, anticorps spam1

Sujet: Hyaluronidase degrades hyaluronic acid, a major structural proteoglycan found in extracellular matrices and basement membranes. Six members of the hyaluronidase family are clustered into two tightly linked groups on chromosome 3p21.3 and 7q31.3. This gene was previously referred to as HYAL1 and HYA1 and has since been assigned the official symbol SPAM1, another family member on chromosome 3p21.3 has been assigned HYAL1. This gene encodes a GPI-anchored enzyme located on the human sperm surface and inner acrosomal membrane. This multifunctional protein is a hyaluronidase that enables sperm to penetrate through the hyaluronic acid-rich cumulus cell layer surrounding the oocyte, a receptor that plays a role in hyaluronic acid induced cell signaling, and a receptor that is involved in sperm-zona pellucida adhesion. Abnormal expression of this gene in tumors has implicated this protein in degradation of basement membranes leading to tumor invasion and metastasis. Multiple transcript variants encoding different isoforms have been found for this gene.

Alias Symbols: SPAM1, HYAL3, PH20,

Protein Size: 509

ID gène: 6677

NCBI Accession: NP_694859

UniProt: P38567