CD11b anticorps (N-Term)

N° du produit ABIN5518692

Détail du produit anti-CD11b anticorps

Antigène: CD11b (ITGAM) (Integrin alpha M (ITGAM))

Épitope: AA 177-192, N-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CD11b est non-conjugé

Application: Western Blotting (WB)

Fonction: Rabbit IgG polyclonal antibody for Integrin alpha-M(ITGAM) detection. Tested with WB in Human,Mouse,Rat.

Séquence: MEQLKKSKTL FSLMQY

Réactivité croisée (Details): No cross reactivity with other proteins.

Attributs du produit: Rabbit IgG polyclonal antibody for Integrin alpha-M(ITGAM) detection. Tested with WB in Human,Mouse,Rat.
Gene Name: integrin, alpha M(complement component 3 receptor 3 subunit)
Protein Name: Integrin alpha-M

Purification: Immunogen affinity purified.

Immunogène: A synthetic peptide corresponding to a sequence at the N-terminus of human CD11b(177-192aa MEQLKKSKTLFSLMQY), different from the related mouse sequence by one amino acid, and from the related rat sequence by three amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Predicted Species: Mouse, Rat, The detection limit for ITGAM is approximately 1 ng/lane under reducing conditions.
Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities.
Other applications have not been tested. Optimal dilutions should be determined by end users.

Commentaires:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

Agent conservateur: Sodium azide, Thimerosal (Merthiolate)

Précaution d'utilisation: This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Références pour anticorps anti-CD11b (ABIN5518692)

Mu, Jing, Guo: "Expressions of CD11a, CD11b, and CD11c integrin proteins in rats with myocardial hypertrophy." dans: Iranian journal of basic medical sciences, Vol. 17, Issue 11, pp. 874-8, (2015) (PubMed).

Ren, Zhang, Zhou, Sun, Zhang, Wei, Zhang, Si: "Tanshinone IIA prevents the loss of nigrostriatal dopaminergic neurons by inhibiting NADPH oxidase and iNOS in the MPTP model of Parkinson's disease." dans: Journal of the neurological sciences, Vol. 348, Issue 1-2, pp. 142-52, (2015) (PubMed).

Zhao, Wang, Wang, Sun, Yang, Qiu, Wu, Zhang, Li, Zhang, Zhao, Zou, Ge: "CXCR6 deficiency ameliorated myocardial ischemia/reperfusion injury by inhibiting infiltration of monocytes and IFN-?-dependent autophagy." dans: International journal of cardiology, Vol. 168, Issue 2, pp. 853-62, (2013) (PubMed).

Yuan, Su, Pu, Liu, Chen, Zhu, Zhu, Zhang, He: "Ethyl pyruvate promotes spinal cord repair by ameliorating the glial microenvironment." dans: British journal of pharmacology, Vol. 166, Issue 2, pp. 749-63, (2012) (PubMed).

Leng, Zhan, Wang, Liu, Gong, Gao, Wu, Wang, Zhao, Wang, Zhang, Pang, Qian: "Anti-heat shock protein 70 autoantibody epitope changes and BD091 promotes atherosclerosis in rats." dans: Cell stress & chaperones, Vol. 15, Issue 6, pp. 947-58, (2011) (PubMed).

Shi, Xun, Yue, Zhang, Ren, Wang, Wu, Shi, Yang, Lei: "Cloning, characterization, and expression analysis of goat (Capra hircus) phospholipid hydroperoxide glutathione peroxidase (PHGPx)." dans: International journal of biological sciences, Vol. 6, Issue 4, pp. 316-26, (2010) (PubMed).

Détails sur CD11b

Antigène: CD11b (ITGAM) (Integrin alpha M (ITGAM))

Autre désignation: ITGAM (ITGAM Produits)

Synonymes: anticorps CD11b/CD18, anticorps CR3, anticorps CR3A, anticorps Cd11b, anticorps F730045J24Rik, anticorps Ly-40, anticorps MAC1, anticorps Mac-1, anticorps Mac-1a, anticorps CD11B, anticorps MAC-1, anticorps MAC1A, anticorps MO1A, anticorps SLEB6, anticorps C3bi, anticorps integrin subunit alpha M, anticorps integrin alpha M, anticorps integrin, alpha M (complement component 3 receptor 3 subunit), anticorps integrin alpha-M, anticorps ITGAM, anticorps Itgam, anticorps LOC100351865

Sujet: ITGAM(Integrin Alpha-M), also called CD11B or Mo1 ALPHA SUBUNIT(MO1A), is one protein subunit that forms the heterodimeric integrin alpha-M beta-2(alphaMbeta2) molecule. A major surface antigen family on human leukocytes includes complement receptor type 3(CR3A, also called ITGAM, Mac1, or Mo1), lymphocyte function-associated(LFA) antigen type 1(ITGAL), and p150, 95(ITGAX). By in situ hybridization, Corbi et al.(1988) demonstrated that the genes encoding the alpha subunits of LFA1(ITGAL), Mac1, and p150, 95(ITGAX), all of which are involved in leukocyte adhesion, constitute a cluster on 16p13.1-p11. Callen et al.(1991) narrowed the assignment to 16p11.2. Inflammation plays an essential role in the initiation and progression of atherosclerosis. Simon et al.(2000) presented evidence that it also has a role in vascular repair after mechanical arterial injury(i.e., percutaneous transluminal coronary angioplasty, or PTCA).

Synonyms: Antigen CD11b p170 antibody|CD11 antigen like family member B antibody|CD11 antigen-like family member B antibody|CD11b antibody|CD11b antigen antibody|CD11b/CD18 antibody|CD49d antibody|Cell surface glycoprotein MAC 1 alpha subunit antibody|Cell surface glycoprotein MAC-1 subunit alpha antibody|Cell Surface Glycoprotein MAC1 Alpha Subunit antibody|Complement component 3 receptor 3 subunit antibody|Complement Component Receptor 3 Alpha antibody|Complement receptor type 3, alpha subunit antibody|CR 3 alpha chain antibody|CR-3 alpha chain antibody|CR3 Alpha Chain antibody|CR3 antibody|CR3A antibody|F730045J24Rik antibody|Integrin Alpha M antibody|Integrin alpha M chain antibody|Integrin alpha M complement component 3 receptor 3 subunit antibody|Integrin alpha-M antibody|Integrin beta 2 alpha subunit antibody|ITAM_HUMAN antibody|ITGAM antibody|Leukocyte Adhesion Receptor MO1 antibody|Ly-40 antibody|MAC 1 antibody|Mac-1a antibody|MAC1 antibody|Mac1, alpha subunit antibody|MAC1A antibody|Macrophage antigen alpha polypeptide antibody|MGC117044 antibody|Mo1, alpha subunit antibody|MO1A antibody|Neutrophil adherence receptor alpha M subunit antibody|Neutrophil Adherence Receptor antibody|SLEB6 antibody

UniProt: P11215

Pathways: Apoptose, Activation of Innate immune Response, Toll-Like Receptors Cascades, Activated T Cell Proliferation