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SOS1 anticorps (AA 934-962)

SOS1 Reactivité: Humain WB, IHC (p) Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN5537593
  • Antigène Voir toutes SOS1 Anticorps
    SOS1 (Son of Sevenless Homolog 1 (SOS1))
    Épitope
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 934-962
    Reactivité
    • 26
    • 12
    • 6
    • 5
    • 5
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    Humain
    Hôte
    • 17
    • 11
    • 1
    Lapin
    Clonalité
    • 18
    • 11
    Polyclonal
    Conjugué
    • 26
    • 1
    • 1
    • 1
    Cet anticorp SOS1 est non-conjugé
    Application
    • 21
    • 14
    • 9
    • 5
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Purification
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogène
    This SOS1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 934-962 amino acids from the Central region of human SOS1.
    Isotype
    Ig Fraction
    Top Product
    Discover our top product SOS1 Anticorps primaire
  • Indications d'application
    For WB starting dilution is: 1:2000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Supplied in PBS with 0.09 % (W/V) sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
  • Antigène
    SOS1 (Son of Sevenless Homolog 1 (SOS1))
    Autre désignation
    SOS1 (SOS1 Produits)
    Synonymes
    anticorps GF1, anticorps GGF1, anticorps GINGF, anticorps HGF, anticorps NS4, anticorps 4430401P03Rik, anticorps 9630010N06, anticorps AI449023, anticorps SOS Ras/Rac guanine nucleotide exchange factor 1, anticorps son of sevenless homolog 1 (Drosophila), anticorps SOS1, anticorps Sos1
    Classe de substances
    Viral Protein
    Sujet
    Son of Sevenless 1 protein is an activator of ras proteins by stimulating the exchange of GDP for GTP on ras. Murine Son of Sevenless proteins have been shown to form a complex with activated EGF receptor, coupling tyrosine kinases to ras proteins. The SOS gene was originally isolated in Drosophila. Two mammalian homologues (mSOS1 and mSOS2) have been isolated from a mouse cDNA library and are expressed in a variety of mouse embryo and adult tissues. Human SOS1 and SOS2 homologs have also been isolated. The two mouse homologs are approximately 70 % identical in composition. The mammalian SOS1 protein has a highly specific guanine nucleotide exchange activity towards p21ras. In epidermal growth factor stimulated cells, SOS1 interacts with SH3 domains of GRB2 and binds via SH2 domain to tyrosine 1068 of activated Epidermal Growth Factor receptor.
    Poids moléculaire
    152 kDa
    ID gène
    6654
    UniProt
    Q07889
    Pathways
    Signalisation RTK, TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Hepatitis C, Signaling Events mediated by VEGFR1 and VEGFR2, Signaling of Hepatocyte Growth Factor Receptor, BCR Signaling
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