FAIM3 anticorps (C-Term)

N° du produit ABIN501016

Détail du produit anti-FAIM3 anticorps

Antigène: FAIM3 (Fas Apoptotic Inhibitory Molecule 3 (FAIM3))

Épitope: C-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FAIM3 est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificité: This antibody detects FAIM3 / TOSO.

Réactivité croisée (Details): Species reactivity (tested):Human

Purification: Affinity chromatography

Immunogène: Toso antibody was raised against a 13 amino acid peptide from near the carboxy terminus of human Toso.

Isotype: IgG

Information d'application

Indications d'application: ELISA. Western blot: 1 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: PBS containing 0.02 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Détails sur FAIM3

Antigène: FAIM3 (Fas Apoptotic Inhibitory Molecule 3 (FAIM3))

Autre désignation: FAIM3 / TOSO (FAIM3 Produits)

Synonymes: anticorps FAIM3, anticorps FCMR, anticorps TOSO, anticorps 1810037B05Rik, anticorps FcmuR, anticorps Toso, anticorps Fc fragment of IgM receptor, anticorps FCMR, anticorps Fcmr

Sujet: Apoptosis is an important process by which normal tissue homeostasis and function are maintained. One of the major signals that regulate this process is mediated by the activation of the Fas receptor by its ligand. This leads to the formation of a Fas-associated death domain (FADD)- containing death-inducing signaling complex and the activation of caspase-8, which in turn activates downstream effector caspases, such as caspase-3 and -7. Recent experiments have shown that overexpression of Toso, a novel regulator of Fas-induced apoptosis in lymphoid cells, in Jurkat cells as well as transgenic mice render these cells resistant to Fas-induced apoptosis but not to TRAIL-induced apoptosis. Furthermore, Toso was found to associate with FADD, suggesting that Toso functions by disrupting the formation of the death-inducing signaling complex. Despite its predicted molecular weight, Toso often migrates at 60 kDa in SDS-PAGE.Synonyms: Fas apoptotic inhibitory molecule 3, Regulator of Fas-induced apoptosis Toso

ID gène: 9214

NCBI Accession: NP_005440