Bcl-2 anticorps
Aperçu rapide pour Bcl-2 anticorps (ABIN5557347)
Antigène
Voir toutes Bcl-2 (BCL2) AnticorpsReactivité
Hôte
Clonalité
Conjugué
Application
Clone
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Réactivité croisée
- Humain, Souris
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Purification
- Purified by Protein A.
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Immunogène
- Recombinant human BCL-2 protein, around 50-150aa.
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Isotype
- IgG2b
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Indications d'application
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WB 1:300-5000
IHC-P 1:200-400
IF(ICC) 1:50-200 -
Restrictions
- For Research Use only
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Format
- Liquid
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Concentration
- 1 μg/μL
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Buffer
- Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.
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Agent conservateur
- ProClin
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Précaution d'utilisation
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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Stock
- 4 °C,-20 °C
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Stockage commentaire
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
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Date de péremption
- 12 months
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- Bcl-2 (BCL2) (B-Cell CLL/lymphoma 2 (BCL2))
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Autre désignation
- BCL-2
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Sujet
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Synonyms: Apoptosis regulator Bcl-2, BCL2
Background: Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (PubMed:17418785).
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ID gène
- 596
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UniProt
- P10415
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Pathways
- Signalisation MAPK, Signalisation PI3K-Akt, Apoptose, Caspase Cascade in Apoptosis, Regulation of Muscle Cell Differentiation, Cell-Cell Junction Organization, Skeletal Muscle Fiber Development, Autophagy, Smooth Muscle Cell Migration, Negative Regulation of intrinsic apoptotic Signaling
Antigène
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