BTRC anticorps (AA 24-151)

N° du produit ABIN5611131

L’anticorps Souris Monoclonal anti-BTRC a été validé pour WB, ELISA, IHC et FACS. Il convient pour détecter BTRC dans des échantillons de Humain.

Aperçu rapide pour BTRC anticorps (AA 24-151) (ABIN5611131)

Antigène: BTRC (beta-Transducin Repeat Containing (BTRC))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp BTRC est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS)

Clone: 4C5D8

Détail du produit anti-BTRC anticorps

Épitope: AA 24-151

Fonction: BTRC Antibody

Purification: Purified antibody

Immunogène: Purified recombinant fragment of human BTRC (AA: 24-151) expressed in E. Coli.

Isotype: IgG1

Information d'application

Indications d'application:

ELISA: 1/10000

FCM: 1/200 - 1/400

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Détails sur BTRC

Antigène: BTRC (beta-Transducin Repeat Containing (BTRC))

Autre désignation: BTRC

Sujet: This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class, in addition to an F-box, this protein contains multiple WD-40 repeats. The encoded protein mediates degradation of CD4 via its interaction with HIV-1 Vpu. It has also been shown to ubiquitinate phosphorylated NFKBIA (nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha), targeting it for degradation and thus activating nuclear factor kappa-B. Alternatively spliced transcript variants have been described. A related pseudogene exists in chromosome 6.

Poids moléculaire: 68.9 kDa

ID gène: 8945

UniProt: Q9Y297

Pathways: Cycle Cellulaire, Signalisation Hedgehog