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BTRC anticorps (N-Term)

BTRC Reactivité: Humain, Souris, Rat WB, ELISA, IHC, IF, ICC Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN6260326
  • Antigène Voir toutes BTRC Anticorps
    BTRC (beta-Transducin Repeat Containing (BTRC))
    Épitope
    • 9
    • 8
    • 6
    • 5
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    N-Term
    Reactivité
    • 44
    • 15
    • 11
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    Humain, Souris, Rat
    Hôte
    • 43
    • 5
    Lapin
    Clonalité
    • 43
    • 5
    Polyclonal
    Conjugué
    • 21
    • 6
    • 6
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp BTRC est non-conjugé
    Application
    • 28
    • 23
    • 19
    • 16
    • 6
    • 4
    • 3
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
    Specificité
    BTRC Antibody detects endogenous levels of total BTRC.
    Homologie
    Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus
    Purification
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogène
    A synthesized peptide derived from human BTRC, corresponding to a region within N-terminal amino acids.
    Isotype
    IgG
    Top Product
    Discover our top product BTRC Anticorps primaire
  • Indications d'application
    WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20 °C. Stable for 12 months from date of receipt.
    Date de péremption
    12 months
  • Antigène
    BTRC (beta-Transducin Repeat Containing (BTRC))
    Autre désignation
    BTRC (BTRC Produits)
    Synonymes
    anticorps BTRC, anticorps Beta-TrCP, anticorps betaTrCP, anticorps btrcp, anticorps btrcp1, anticorps fbw1a, anticorps fbxw1, anticorps fbxw1a, anticorps fwd1, anticorps btrc, anticorps beta-TrCP, anticorps BETA-TRCP, anticorps FBW1A, anticorps FBXW1, anticorps FBXW1A, anticorps FWD1, anticorps bTrCP, anticorps bTrCP1, anticorps beta-TrCP1, anticorps btrc-a, anticorps Beta-Trcp1, anticorps Fbw1a, anticorps HOS, anticorps Slimb, anticorps b-TrCP, anticorps mKIAA4123, anticorps beta-transducin repeat containing E3 ubiquitin protein ligase, anticorps beta-transducin repeat containing, anticorps beta-TrCP, anticorps beta-transducin repeat containing E3 ubiquitin protein ligase S homeolog, anticorps beta-transducin repeat containing protein, anticorps BTRC, anticorps btrc, anticorps LOC100634006, anticorps Btrc, anticorps btrc.S
    Sujet

    Description: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds to phosphorylated target proteins (PubMed:10066435, PubMed:10497169, PubMed:10644755, PubMed:10835356, PubMed:11238952, PubMed:11359933, PubMed:11994270, PubMed:12791267, PubMed:12902344, PubMed:14603323, PubMed:14681206, PubMed:14988407, PubMed:15448698, PubMed:15917222, PubMed:16371461, PubMed:25503564, PubMed:25704143, PubMed:9859996). SCF(BTRC) mediates the ubiquitination of CTNNB1 and participates in Wnt signaling (PubMed:12077367, PubMed:12820959). SCF(BTRC) mediates the ubiquitination of phosphorylated NFKB1, ATF4, CDC25A, DLG1, FBXO5, PER1, SMAD3, SMAD4, SNAI1 and probably NFKB2 (PubMed:10835356, PubMed:11238952, PubMed:14681206, PubMed:14603323). SCF(BTRC) mediates the ubiquitination of NFKBIA, NFKBIB and NFKBIE, the degradation frees the associated NFKB1 to translocate into the nucleus and to activate transcription (PubMed:10066435, PubMed:10497169, PubMed:10644755). Ubiquitination of NFKBIA occurs at 'Lys-21' and 'Lys-22' (PubMed:10066435). SCF(BTRC) mediates the ubiquitination of CEP68, this is required for centriole separation during mitosis (PubMed:25704143, PubMed:25503564). SCF(BTRC) mediates the ubiquitination and subsequent degradation of nuclear NFE2L1 (By similarity). Has an essential role in the control of the clock-dependent transcription via degradation of phosphorylated PER1 and PER2 (PubMed:15917222). May be involved in ubiquitination and subsequent proteasomal degradation through a DBB1-CUL4 E3 ubiquitin-protein ligase. Required for activation of NFKB-mediated transcription by IL1B, MAP3K14, MAP3K1, IKBKB and TNF. Required for proteolytic processing of GLI3 (PubMed:16371461).

    Gene: BTRC

    Poids moléculaire
    69kDa
    ID gène
    8945
    UniProt
    Q9Y297
    Pathways
    Cycle Cellulaire, Signalisation Hedgehog
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