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APAF1 anticorps (C-Term)
APAF1
Reactivité: Humain, Souris, Rat
IHC (p)
Hôte: Lapin
Polyclonal
unconjugated
N° du produit ABIN5611436
Détail du produit anti-APAF1 anticorps
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Antigène
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APAF1
(Apoptotic Peptidase Activating Factor 1 (APAF1))
Épitope
Tous les épitopes à travers APAF1 Anticorps.
C-Term
Reactivité
Toutes les réactivités sur APAF1 Anticorps
Humain, Souris, Rat
Hôte
Toutes les hôtes sur APAF1 Anticorps
Lapin
Clonalité
Toutes les clonalités sur APAF1 Anticorps
Polyclonal
Conjugué
Tous les conjugués à travers APAF1 Anticorps
Cet anticorp APAF1 est non-conjugé
Application
Tous les applications à travers APAF1 Anticorps.
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Specificité
This antibody reacts to Apoptotic Protease Activating Factor 1 (APAF1).
Purification
Immunoaffinity Chromatography
Immunogène
APAF1 antibody was raised against a synthetic peptide derived from the C-terminus of human Apaf-1 Genename: APAF1
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Information d'application
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Indications d'application
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Stockage
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Buffer
10 mM PBS, pH 7.4, BSA, sodium azide.
Agent conservateur
Sodium azide
Précaution d'utilisation
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Stock
4 °C
Stockage commentaire
Store the antibody undiluted at 2-8 °C. DO NOT FREEZE!
Détails sur APAF1
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Antigène
APAF1
(Apoptotic Peptidase Activating Factor 1 (APAF1))
Autre désignation
APAF1 (APAF1 Produits )
Synonymes
anticorps APAF1, anticorps ARK, anticorps Apaf-1, anticorps Apaf1, anticorps CG6829, anticorps D-Apaf-1, anticorps DARK, anticorps Dapaf-1, anticorps Dapaf-1/HAC-1, anticorps Dark, anticorps Dark/Apaf-I, anticorps Dark/Dapaf-1/HAC1, anticorps Dark/Hac-1/dApaf-1, anticorps Dark/Hac-1/dApaf1, anticorps Dmel\\CG6829, anticorps Hac-1, anticorps Hac-1/Dark, anticorps Hac1, anticorps T1, anticorps anon-53Fa, anticorps apaf-1, anticorps apaf1, anticorps arc, anticorps ark, anticorps dAPAF-1, anticorps dApaf-1, anticorps dApaf-1/DARK/HAC-1, anticorps dApaf1, anticorps dArk, anticorps dapaf, anticorps dapaf-1, anticorps dapaf-1L, anticorps dapaf-1S, anticorps dark, anticorps dark/dapaf-1/hac-1, anticorps dark/hac-1/dapaf-1, anticorps hac-1, anticorps hac1, anticorps l(2)SH0173, anticorps APAF-1, anticorps CED4, anticorps 6230400I06Rik, anticorps Apaf1l, anticorps fog, anticorps mKIAA0413, anticorps zgc:136543, anticorps Death-associated APAF1-related killer, anticorps apoptotic peptidase activating factor 1 L homeolog, anticorps apoptotic peptidase activating factor 1, anticorps Dark, anticorps apaf1.L, anticorps apaf1, anticorps APAF1, anticorps Apaf1
Sujet
Apaf1 has been described as the core of the apoptosome. Deficiency in murine Apaf1 leads to embryonic lethality with a phenotype affecting many aspects of developmental apoptosis. In the developing brain, Apaf1 is a death regulator of the neuronal founder cells. Combined intercrosses of mouse lines mutant for members of the mitochondrial death pathway are providing us with some clues about the relative regulation existing among neuronal cell populations. Apaf1-deficient embryos display an interesting phenotype in the inner ear and in limb development, which involves different caspase-dependent and -independent pathways. Moreover, APAF1 is mutated in human melanomas, and its depletion contributes to malignant transformation in a mouse model of cancer.Synonyms: Apaf-1, Apoptotic protease-activating factor 1, KIAA0413
ID gène
317
NCBI Accession
NP_001151
UniProt
O14727
Pathways
Signalisation p53 , Apoptose , Caspase Cascade in Apoptosis , Tube Formation , Positive Regulation of Endopeptidase Activity
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