NOTCH3 anticorps (AA 47-156)

N° du produit ABIN562028

Il existe 7+ publications pour ce produit. L’anticorps anti-NOTCH3 Monoclonal Souris est utilisé pour la détection de NOTCH3 dans des échantillons de Humain. Il a été validé pour WB et ELISA.

Aperçu rapide pour NOTCH3 anticorps (AA 47-156) (ABIN562028)

Antigène: NOTCH3 (Notch 3 (NOTCH3))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp NOTCH3 est non-conjugé

Application: Western Blotting (WB), ELISA

Clone: 1G5

Détail du produit anti-NOTCH3 anticorps

Épitope: AA 47-156

Fonction: Mouse monoclonal antibody raised against a partial recombinant NOTCH3.

Séquence: SPCANGGRCT QLPSREAACL CPPGWVGERC QLEDPCHSGP CAGRGVCQSS VVAGTARFSC RCPRGFRGPD CSLPDPCLSS PCAHGARCSV GPDGRFLCSC PPGYQGRSCR

Réactivité croisée: Humain

Attributs du produit: Antibody Reactive Against Recombinant Protein.

Immunogène: NOTCH3 (NP_000426, 47 a.a. ~ 156 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Isotype: IgG2a

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Buffer: In 1x PBS, pH 7.4

Conseil sur la manipulation: Aliquot to avoid repeated freezing and thawing.

Stock: -20 °C

Stockage commentaire: Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.

Références pour anticorps anti-NOTCH3 (ABIN562028)

Meng, Zhang, Lee, Wang: "Von Willebrand factor inhibits mature smooth muscle gene expression through impairment of Notch signaling." dans: PLoS ONE, Vol. 8, Issue 9, pp. e75808, (2013) (PubMed).

Watanabe-Hosomi, Watanabe, Tanaka, Nakagawa, Mizuno: "Transendocytosis is impaired in CADASIL-mutant NOTCH3." dans: Experimental neurology, Vol. 233, Issue 1, pp. 303-11, (2012) (PubMed).

Tada, Itoh, Ishii-Watabe, Suzuki, Kawasaki: "Functional analysis of the Notch ligand Jagged1 missense mutant proteins underlying Alagille syndrome." dans: The FEBS journal, Vol. 279, Issue 12, pp. 2096-107, (2012) (PubMed).

Dong, Blaivas, Wang: "Bidirectional encroachment of collagen into the tunica media in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy." dans: Brain research, Vol. 1456, pp. 64-71, (2012) (PubMed).

Lee, Meng, Elmadhoun, Blaivas, Wang: "Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy affecting an African American man: identification of a novel 15-base pair NOTCH3 duplication." dans: Archives of neurology, Vol. 68, Issue 12, pp. 1584-6, (2011) (PubMed).

Meng, Zhang, Hankenson, Wang: "Thrombospondin 2 potentiates notch3/jagged1 signaling." dans: The Journal of biological chemistry, Vol. 284, Issue 12, pp. 7866-74, (2009) (PubMed).

Park, Shih, Wang: "Identification of Pbx1, a potential oncogene, as a Notch3 target gene in ovarian cancer." dans: Cancer research, Vol. 68, Issue 21, pp. 8852-60, (2008) (PubMed).

Détails sur NOTCH3

Antigène: NOTCH3 (Notch 3 (NOTCH3))

Autre désignation: NOTCH3

Sujet: Full Gene Name: Notch homolog 3 (Drosophila)
Synonyms: CADASIL,CASIL

ID gène: 4854

NCBI Accession: NM_000435

Pathways: Signalisation Notch