alpha Actinin 4 anticorps

N° du produit ABIN5647002

Détail du produit anti-alpha Actinin 4 anticorps

Antigène: alpha Actinin 4 (ACTN4) (Actinin, alpha 4 (ACTN4))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp alpha Actinin 4 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: Antigen affinity purified

Immunogène: Amino acids E561-V661 from the human protein were used as the immunogen for the ACTN4 antibody.

Isotype: IgG

Information d'application

Indications d'application: Western blot: 0.5-1 μg/mL,IHC (FFPE): 1-2 μg/mL

Restrictions: For Research Use only

Stockage

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: -20 °C

Stockage commentaire: Prior to reconstitution, store at 4°C. After reconstitution, the ACTN4 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Détails sur alpha Actinin 4

Antigène: alpha Actinin 4 (ACTN4) (Actinin, alpha 4 (ACTN4))

Autre désignation: ACTN4 / Alpha Actinin 4 (ACTN4 Produits)

Synonymes: anticorps fsgs, anticorps fsgs1, anticorps C77391, anticorps ACTININ-4, anticorps FSGS, anticorps FSGS1, anticorps wu:fb53f05, anticorps zgc:63508, anticorps actinin alpha 4, anticorps actinin, alpha 4, anticorps actinin alpha 4 S homeolog, anticorps actn4, anticorps ACTN4, anticorps Actn4, anticorps actn4.S

Sujet: Alpha-actinin-4 is a protein that in humans is encoded by the ACTN4 gene. Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This ACTN4 gene encodes a nonmuscle, alpha actinin isoform which is concentrated in the cytoplasm, and thought to be involved in metastatic processes. Mutations in this gene have been associated with focal and segmental glomerulosclerosis.

UniProt: O43707

Pathways: Proton Transport