CHD5 anticorps (AA 64-98)

N° du produit ABIN5647082

Détail du produit anti-CHD5 anticorps

Antigène: CHD5 (Chromodomain Helicase DNA Binding Protein 5 (CHD5))

Épitope: AA 64-98

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CHD5 est non-conjugé

Application: Western Blotting (WB)

Purification: Antigen affinity purified

Immunogène: A portion of amino acids 64-98 from the human protein was used as the immunogen for the CHD5 antibody.

Isotype: Ig Fraction

Information d'application

Indications d'application: Western blot: 1:1000-2000

Restrictions: For Research Use only

Stockage

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the CHD5 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Détails sur CHD5

Antigène: CHD5 (Chromodomain Helicase DNA Binding Protein 5 (CHD5))

Autre désignation: CHD5 / Chromodomain-helicase-DNA-binding protein 5 (CHD5 Produits)

Synonymes: anticorps CHD-5, anticorps 4930532L22Rik, anticorps AW060752, anticorps B230399N07Rik, anticorps CHD5, anticorps chromodomain helicase DNA binding protein 5, anticorps potassium voltage-gated channel subfamily A regulatory beta subunit 2, anticorps CHD5, anticorps Chd5, anticorps chd5, anticorps KCNAB2

Sujet: Chromodomain-helicase-DNA-binding protein 5 is a chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. May specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non- methylated 'Lys-4' of histone H3. Plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys- 27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. Tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. Downstream activated genes may include CDKN2A that positively regulates the p53/TP53 pathway, which in turn, prevents cell proliferation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa.

ID gène: 26038

UniProt: Q8TDI0