MAP2K6 anticorps (AA 205-209)

N° du produit ABIN5689477

L’anticorps anti-MAP2K6 Polyclonal Lapin est utilisé pour la détection de MAP2K6 dans des échantillons de Humain. Il a été validé pour WB, IHC et IF.

Aperçu rapide pour MAP2K6 anticorps (AA 205-209) (ABIN5689477)

Antigène: MAP2K6 (Mitogen-Activated Protein Kinase Kinase 6 (MAP2K6))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MAP2K6 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Détail du produit anti-MAP2K6 anticorps

Épitope: AA 205-209

Specificité: This antibody detects endogenous level of total MKK6 protein.

Purification: Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Immunogène: MKK6 (Ab-207) antibody was raised against a peptide sequence around aa.205~209 (V-D-S-V-A) derived from Human MKK6.

Information d'application

Indications d'application: Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100, Immunofluorescence: 1:100~1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+),  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store antibody at -20°C for up to one year.

Détails sur MAP2K6

Antigène: MAP2K6 (Mitogen-Activated Protein Kinase Kinase 6 (MAP2K6))

Autre désignation: MKK6

Sujet: MEK6 is a member of MAPKK protein kinase family. By using degenerate oligonucleotide primers from the conserved kinase domains of MKK3 and MKK4 two human cDNAs and 1 murine cDNA encoding closely related proteins of the MKK family were cloned. The two human clones appear to be different isoforms of the same gene generated by differential splicing: the shorter clone was designated MKK6, encodes a 278-amino acid protein, while the longer clone, designated MKK6b, encodes a 334-amino acid protein. MKK6 is about 80 % identical to MKK3 and 40 % identical to MKK4. 1.7-kb human MKK6 transcript is highly expressed in skeletal muscle, while an MKK6b-specific probe detected mRNA bands of 1.8, 2.4, and 4.5 kb that are enriched in heart, skeletal muscle, pancreas and liver. MKK6 plays an important role in intracellular signaling pathways leading toward activation of the p38 MAP kinase . MEK6 phosphorylates and activates p38 in response to inflammatory cytokines or environmental stress. As an essential component of p38 MAPK mediated signal transduction pathway, this gene is involved in many cellular processes such as stress induced cell cycle arrest, transcription activation and apoptosis.

Poids moléculaire: 41 kDa

ID gène: 5608

NCBI Accession: NP_002749

UniProt: P52564

Pathways: Signalisation MAPK, Signalisation TLR, Activation of Innate immune Response, Regulation of Muscle Cell Differentiation, Toll-Like Receptors Cascades