FLT3 anticorps (AA 589-593)

N° du produit ABIN5689528

L’anticorps Lapin Polyclonal anti-FLT3 a été validé pour WB et IF. Il convient pour détecter FLT3 dans des échantillons de Humain.

Aperçu rapide pour FLT3 anticorps (AA 589-593) (ABIN5689528)

Antigène: FLT3 (Fms-Related tyrosine Kinase 3 (FLT3))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FLT3 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF)

Détail du produit anti-FLT3 anticorps

Épitope: AA 589-593

Specificité: This antibody detects endogenous level of total FLT3 protein.

Purification: Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Immunogène: FLT3 (Ab-591) antibody was raised against a peptide sequence around aa.589~593 (Y-F-Y-V-D) derived from Human FLT3.

Information d'application

Indications d'application: Western Blot: 1:500~1:1000, Immunofluorescence: 1:100~1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+),  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store antibody at -20°C for up to one year.

Détails sur FLT3

Antigène: FLT3 (Fms-Related tyrosine Kinase 3 (FLT3))

Autre désignation: FLT3

Sujet: FLT3 encodes a class III receptor tyrosine kinase that regulates hematopoiesis. The receptor consists of an extracellular domain composed of five immunoglobulin-like domains, one transmembrane region, and a cytoplasmic kinase domain split into two parts by a kinase-insert domain. The receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia.

Poids moléculaire: 130, 160 kDa

ID gène: 2322

NCBI Accession: NP_004110

UniProt: P36888

Pathways: Signalisation RTK