CHEK2 anticorps (AA 514-518)

N° du produit ABIN5689596

Cet anticorps Lapin Polyclonal détecte spécifiquement CHEK2 dans WB. Il présente une réactivité envers Humain.

Aperçu rapide pour CHEK2 anticorps (AA 514-518) (ABIN5689596)

Antigène: CHEK2 (Checkpoint Kinase 2 (CHEK2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CHEK2 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-CHEK2 anticorps

Épitope: AA 514-518

Specificité: This antibody detects endogenous levels of total Chk2 protein.

Purification: Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Immunogène: Chk2 (Ab-516) antibody was raised against a peptide sequence around aa. 514~518 (Q-P-S-T-S) derived from Chk2.

Information d'application

Indications d'application: Western Blot: 1:500~1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+),  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store antibody at -20°C for up to one year.

Détails sur CHEK2

Antigène: CHEK2 (Checkpoint Kinase 2 (CHEK2))

Autre désignation: Chk2

Sujet: The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Plays a central role in DNA repair by facilitating cellular response to DNA repair. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. Involved in transcriptional regulation of P21 in response to DNA damage. Required for FANCD2 targeting to sites of DNA damage. May function as a transcriptional regulator. Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation

Poids moléculaire: 62 kDa

ID gène: 11200

NCBI Accession: NP_001005735

UniProt: O96017

Pathways: Signalisation p53, Apoptose, Cycle Cellulaire