FGFR3 anticorps (AA 630-680)

N° du produit ABIN5689961

Cet anticorps anti-FGFR3 Polyclonal Lapin (ABIN5689961) détecte spécifiquement FGFR3 dans WB, ELISA, IF et IHC (p). L’anticorps est réactif avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour FGFR3 anticorps (AA 630-680) (ABIN5689961)

Antigène: FGFR3 (Fibroblast Growth Factor Receptor 3 (FGFR3))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FGFR3 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-FGFR3 anticorps

Épitope: AA 630-680

Specificité: FGFR3 antibody is human, mouse and rat reactive. At least three isoforms of FGFR3 are known to exist, this antibody will detect all three.

Purification: FGFR3 Antibody is affinity chromatography purified via peptide column.

Immunogène: FGFR3 antibody was raised against a 19 amino acid peptide near the carboxy terminus of human FGFR3.

The immunogen is located within amino acids 630 - 680 of FGFR3.

Isotype: IgG

Information d'application

Indications d'application: FGF3 antibody can be used for detection of FGFR3 by Western blot at 1 - 2 μ,g/mL.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: FGFR3 Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: FGFR3 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Détails sur FGFR3

Antigène: FGFR3 (Fibroblast Growth Factor Receptor 3 (FGFR3))

Autre désignation: FGFR3

Sujet: FGFR3 Antibody: FGFR3 is a tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation and apoptosis (1). It is required for normal skeleton development and promotes apoptosis in chondrocytes and cancer cell proliferation. FGFR3 protein contains three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain (1,2). It is alternatively spliced to produce three isoforms that are expressed in brain, kidney and testis. Defects in FGFR3 are associated with several diseases, including achondroplasia and hypochondroplasia (3,4). Mutations in FGFR3 are also a cause of some bladder and cervical cancers (5).

Poids moléculaire: Predicted: 89 kDa

Observed: 9+2, 98 kDa

ID gène: 2261

NCBI Accession: NP_001156685

UniProt: P22607

Pathways: Signalisation RTK, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Stem Cell Maintenance, Growth Factor Binding