MALT1 anticorps (AA 630-680)

N° du produit ABIN5690045

Cet anticorps anti-MALT1 Polyclonal Lapin (ABIN5690045) détecte spécifiquement MALT1 dans WB, IF, ELISA et IHC (p). L’anticorps est réactif avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour MALT1 anticorps (AA 630-680) (ABIN5690045)

Antigène: MALT1 (Mucosa Associated Lymphoid Tissue Lymphoma Translocation Gene 1 (MALT1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MALT1 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-MALT1 anticorps

Épitope: AA 630-680

Specificité: MALT1 antibody is human, mouse and rat reactive. At least two isoforms of MALT1 are known to exist, this antibody will detect both isoforms.

Purification: MALT1 antibody is affinity chromatography purified via peptide column.

Immunogène: MALT1 antibody was raised against an 18 amino acid peptide near the carboxy terminus of human MALT1.

The immunogen is located within amino acids 630 - 680 of MALT1.

Isotype: IgG

Information d'application

Indications d'application: MALT1 antibody can be used for detection of MALT1 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: MALT1 antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: MALT1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Détails sur MALT1

Antigène: MALT1 (Mucosa Associated Lymphoid Tissue Lymphoma Translocation Gene 1 (MALT1))

Autre désignation: MALT1

Sujet: MALT1 was initially identified as a novel gene that was recurrently rearranged in t(11,18)(q21,q21) mucosa-associated lymphoid tissue lymphomas along with the apoptosis inhibitor protein c-IAP2 (1). MALT1, along with the proteins CARMA1 and Bcl10 form an NF-kappaB-activating complex, termed the CBM signalsome, that acts downstream of lymphocyte antigen receptors as well as many other non-lymphoid cell-surface receptors that play a role in multiple cellular functions (2,3). MALT1 has proteolytic activity, and this activity is critical for full NF-kappaB response in T cell activation (4).

Poids moléculaire: Predicted: 91 kDa

Observed: 96 kDa

ID gène: 10892

NCBI Accession: NP_006776

UniProt: Q9UDY8

Pathways: TCR Signaling, Fc-epsilon Receptor Signaling Pathway, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, BCR Signaling, Ubiquitin Proteasome Pathway, S100 Proteins