MALT1 anticorps (AA 630-680)

N° du produit ABIN5690045

Cet anticorps anti-MALT1 est un anticorps Lapin Polyclonal détectant MALT1 dans WB, IF, ELISA et IHC (p). Adapté pour Humain, Souris et Rat.

Aperçu rapide pour MALT1 anticorps (AA 630-680) (ABIN5690045)

Antigène: MALT1 (Mucosa Associated Lymphoid Tissue Lymphoma Translocation Gene 1 (MALT1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MALT1 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-MALT1 anticorps

Épitope: AA 630-680

Specificité: MALT1 antibody is human, mouse and rat reactive. At least two isoforms of MALT1 are known to exist, this antibody will detect both isoforms.

Purification: MALT1 antibody is affinity chromatography purified via peptide column.

Immunogène: MALT1 antibody was raised against an 18 amino acid peptide near the carboxy terminus of human MALT1.

The immunogen is located within amino acids 630 - 680 of MALT1.

Isotype: IgG

Information d'application

Indications d'application: MALT1 antibody can be used for detection of MALT1 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: MALT1 antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: MALT1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Détails sur MALT1

Antigène: MALT1 (Mucosa Associated Lymphoid Tissue Lymphoma Translocation Gene 1 (MALT1))

Autre désignation: MALT1

Sujet: MALT1 was initially identified as a novel gene that was recurrently rearranged in t(11,18)(q21,q21) mucosa-associated lymphoid tissue lymphomas along with the apoptosis inhibitor protein c-IAP2 (1). MALT1, along with the proteins CARMA1 and Bcl10 form an NF-kappaB-activating complex, termed the CBM signalsome, that acts downstream of lymphocyte antigen receptors as well as many other non-lymphoid cell-surface receptors that play a role in multiple cellular functions (2,3). MALT1 has proteolytic activity, and this activity is critical for full NF-kappaB response in T cell activation (4).

Poids moléculaire: Predicted: 91 kDa

Observed: 96 kDa

ID gène: 10892

NCBI Accession: NP_006776

UniProt: Q9UDY8

Pathways: TCR Signaling, Fc-epsilon Receptor Signaling Pathway, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, BCR Signaling, Ubiquitin Proteasome Pathway, S100 Proteins