PJA1 anticorps (AA 50-100)
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- Antigène Voir toutes PJA1 Anticorps
- PJA1 (Praja Ring Finger 1, E3 Ubiquitin Protein Ligase (PJA1))
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Épitope
- AA 50-100
- Reactivité
- Humain, Souris, Rat
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp PJA1 est non-conjugé
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Application
- Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)
- Specificité
- PJA1 antibody is human, mouse and rat reactive. At least two isoforms of PJA1 are known to exist, this antibody will detect both isoforms.
- Purification
- PJA1 antibody is affinity chromatography purified via peptide column.
- Immunogène
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PJA1 antibody was raised against a 19 amino acid peptide near the amino terminus of human PJA1.
The immunogen is located within amino acids 50 - 100 of PJA1. - Isotype
- IgG
- Top Product
- Discover our top product PJA1 Anticorps primaire
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- Indications d'application
- PJA1 antibody can be used for detection of PJA1 by Western blot at 0.25 - 0.5 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- PJA1 antibody is supplied in PBS containing 0.02 % sodium azide.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- 4 °C,-20 °C
- Stockage commentaire
- PJA1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
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- Antigène
- PJA1 (Praja Ring Finger 1, E3 Ubiquitin Protein Ligase (PJA1))
- Autre désignation
- PJA1 (PJA1 Produits)
- Synonymes
- anticorps PRAJA1, anticorps RNF70, anticorps praja ring finger ubiquitin ligase 1, anticorps PJA1, anticorps Pja1
- Sujet
- Ubiquitinization is an important cellular degradation process requiring sequential reactions that are mediated by three enzymes: E1, E2 and E3. PJA1, also known as Praja1 and RING finger protein 70, is a 643 amino acid E2-dependent E3-ubiquitin ligase that is abundantly expressed in the brain (1,2). Through interaction and activation with the E2-ubiquitin ligase UBC4, PJA1 mediates substrate-specific ubiquitination via its RING finger domain and facilitates ubiquitination (3). Overexpression of PJA1 in gastrointestinal cancers suggests that it may be responsible for the degradation of some anti-oncogenic proteins (4,5).
- Poids moléculaire
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Predicted: 71 kDa
Observed: 71 kDa - ID gène
- 64219
- NCBI Accession
- NP_660095
- UniProt
- Q8NG27
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