SMURF2 anticorps (AA 140-190)

N° du produit ABIN5690259

Cet anticorps Lapin Polyclonal détecte spécifiquement SMURF2 dans WB, ELISA, IF et IHC (p). Il présente une réactivité envers Humain, Souris et Rat.

Aperçu rapide pour SMURF2 anticorps (AA 140-190) (ABIN5690259)

Antigène: SMURF2 (SMAD Specific E3 Ubiquitin Protein Ligase 2 (SMURF2))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SMURF2 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-SMURF2 anticorps

Épitope: AA 140-190

Specificité: SMURF2 antibody is human, mouse and rat reactive. SMURF2 is predicted to not cross-react with SMURF1.

Purification: SMURF2 antibody is affinity chromatography purified via peptide column.

Immunogène: SMURF2 antibody was raised against a 17 amino acid peptide near the amino terminus of human SMURF2.

The immunogen is located within amino acids 140 - 190 of SMURF2.

Isotype: IgG

Information d'application

Indications d'application: SMURF2 antibody can be used for detection of SMURF2 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for Immunohistochemistry at 2 μ,g/mL. For Immunoflorescence start at 20 μ,g/mL.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: SMURF2 Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: SMURF2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Détails sur SMURF2

Antigène: SMURF2 (SMAD Specific E3 Ubiquitin Protein Ligase 2 (SMURF2))

Autre désignation: SMURF2

Sujet: SMURF2 (SMAD ubiquitin regulatory factor 2) is a negative regulator of TGF-beta signaling (1). SMURF1 and SMURF2 are members of HECT domain E3 ubiquitin ligase which are involved in the enzymatic reactions of the Ub conjugating pathway (1,2). SMURF2 is widely expressed and was initially identified as an inhibitor of TGF-beta/BMP signaling by targeting R-Smads and TGF type I receptor for ubiquitination and degradation (3). Studies have shown that SMURF2 functions as a tumor suppressor by maintaining genomic stability through targeting RNF20 (3). SMURF2 associates constitutively with SMAD7 (4).

Poids moléculaire: Predicted: 82 kDa

Observed: 85 kDa

ID gène: 64750

NCBI Accession: NP_073576

UniProt: Q9HAU4