TAS2R140 anticorps (AA 100-150)

N° du produit ABIN5690299

Détail du produit anti-TAS2R140 anticorps

Antigène: TAS2R140 (Taste Receptor, Type 2, Member 140 (TAS2R140))

Épitope: AA 100-150

Reactivité: Rat, Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TAS2R140 est non-conjugé

Application: ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)

Specificité: TRB3 antibody is human, mouse and rat reactive. At least two isoforms of TRB3 are known to exist, this antibody will detect both isoforms.

Purification: TRB3 antibody is affinity chromatography purified via peptide column.

Immunogène: TRB3 antibody was raised against a 17 amino acid peptide near the center of human TRB3.

The immunogen is located within amino acids 100 - 150 of TRB3.

Isotype: IgG

Information d'application

Indications d'application: TRB3 antibody can be used for detection of TRB3 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: TRB3 antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: TRB3 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Détails sur TAS2R140

Antigène: TAS2R140 (Taste Receptor, Type 2, Member 140 (TAS2R140))

Autre désignation: TRB3 (TAS2R140 Produits)

Synonymes: anticorps T2R40, anticorps T2r34, anticorps TRB3, anticorps TRB5, anticorps Tas2r13, anticorps Tas2r137, anticorps Tas2r40, anticorps Tas2r8, anticorps mTRB3, anticorps mt2r64, anticorps taste receptor, type 2, member 140, anticorps Tas2r140

Sujet: TRB3 was initially identified as a novel kinase-like gene that was overexpressed in multiple human tumors and regulated by hypoxia (1). In the liver, TRB3 binds and inhibits AKT activity, leading to impaired insulin signaling (2), whereas in adipose tissue TRB3 is involved in the regulation of fatty acid oxidation through ubiquitination of Acetyl-CoA carboxylase (3). Endoplasmic reticulum (ER) stress induces TRB3 expression in skeletal muscle, leading to a decrease in insulin signaling and glucose uptake, suggesting that inhibition of TRB3 expression may be a potential therapeutic treatment for managing insulin resistance (4).

Poids moléculaire: Predicted: 39 kDa

Observed: 39 kDa

ID gène: 57761

NCBI Accession: NP_066981

UniProt: Q96RU7