CTNNB1 anticorps (AA 2-233)

N° du produit ABIN5693091

Cet anticorps Souris Monoclonal détecte spécifiquement CTNNB1 dans WB, IHC, IF, FACS et ICC. Il présente une réactivité envers Humain, Souris et Rat et a été mentionné dans 12+ publications.

Aperçu rapide pour CTNNB1 anticorps (AA 2-233) (ABIN5693091)

Antigène: CTNNB1 (Catenin (Cadherin-Associated Protein), beta 1, 88kDa (CTNNB1))

Reactivité: Humain, Souris, Rat

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CTNNB1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FACS), Immunocytochemistry (ICC)

Clone: 1F6

Détail du produit anti-CTNNB1 anticorps

Épitope: AA 2-233

Fonction: Anti-beta Catenin CTNNB1 Antibody (monoclonal, 1F6)

Réactivité croisée (Details): No cross-reactivity with other proteins.

Attributs du produit: Anti-beta Catenin CTNNB1 Antibody (monoclonal, 1F6) (ABIN5693091). Tested in Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. This is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications.

Purification: Immunogen affinity purified.

Immunogène: E. coli-derived human beta Catenin recombinant protein (Position: A2-K233).

Isotype: IgG1

Information d'application

Indications d'application: Western blot, 0.1-0.5 μg/mL
Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL
Immunocytochemistry/Immunofluorescence, 2 μg/mL
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Références pour anticorps anti-CTNNB1 (ABIN5693091)

Ma, Lv, Sun, Ma, Xing, Wang, Sun, Wang, Li, Li, Zhao: "Naringin ameliorates bone loss induced by sciatic neurectomy and increases Semaphorin 3A expression in denervated bone." dans: Scientific reports, Vol. 6, pp. 24562, (2018) (PubMed).

Jia, Ma, Lv, Ma, Xu, Yang, Tian, Wang, Sun, Xu, Fu, Zhao: "Oestrogen and parathyroid hormone alleviate lumbar intervertebral disc degeneration in ovariectomized rats and enhance Wnt/β-catenin pathway activity." dans: Scientific reports, Vol. 6, pp. 27521, (2018) (PubMed).

Cong, Fu, Zhang, Zhao, Zhang: "Effects of atorvastatin on porcine aqueous humour outflow and trabecular meshwork cells." dans: Experimental and therapeutic medicine, Vol. 15, Issue 1, pp. 210-216, (2018) (PubMed).

Guo, Yi, Li, Fu, Li: "Snail1 is positively correlated with atrial fibrosis in patients with atrial fibrillation and rheumatic heart disease." dans: Experimental and therapeutic medicine, Vol. 14, Issue 5, pp. 4231-4237, (2017) (PubMed).

Pan, An, Meng, Li, Ren, Guan: "MgCl2 and ZnCl2 promote human umbilical vein endothelial cell migration and invasion and stimulate epithelial-mesenchymal transition via the Wnt/β-catenin pathway." dans: Experimental and therapeutic medicine, Vol. 14, Issue 5, pp. 4663-4670, (2017) (PubMed).

Fu, Jiao, Zheng, Liang, Hu: "Combination of lithium chloride and pEGFP-N1-BmK CT effectively decreases proliferation and migration of C6 glioma cells." dans: Cytotechnology, Vol. 68, Issue 2, pp. 197-202, (2016) (PubMed).

Lei, Lai, Bai, Qiu, Yang, Liao, Chuong, Yang, Lian, Zhong: "Prolonged overexpression of Wnt10b induces epidermal keratinocyte transformation through activating EGF pathway." dans: Histochemistry and cell biology, Vol. 144, Issue 3, pp. 209-21, (2016) (PubMed).

Chen, Xue, Shen, Mu, Fu: "Curcumin alleviates glucocorticoid-induced osteoporosis through the regulation of the Wnt signaling pathway." dans: International journal of molecular medicine, Vol. 37, Issue 2, pp. 329-38, (2016) (PubMed).

Shan, Lv, Zhao, Liu, Sun, Xi, Xiao, Li: "Wnt/β-catenin pathway is required for epithelial to mesenchymal transition in CXCL12 over expressed breast cancer cells." dans: International journal of clinical and experimental pathology, Vol. 8, Issue 10, pp. 12357-67, (2016) (PubMed).

Lin, Sun, Wang, Zheng, Zhang, Zheng: "Celastrol Ameliorates Ulcerative Colitis-Related Colorectal Cancer in Mice via Suppressing Inflammatory Responses and Epithelial-Mesenchymal Transition." dans: Frontiers in pharmacology, Vol. 6, pp. 320, (2016) (PubMed).

Wang, Ge, Zhang, Chen, Hu, Li, Ye: "Targeted p53 activation by saRNA suppresses human bladder cancer cells growth and metastasis." dans: Journal of experimental & clinical cancer research : CR, Vol. 35, pp. 53, (2016) (PubMed).

Lei, Guo, Qiu, Lai, Yang, Widelitz, Chuong, Lian, Yang: "Modulating hair follicle size with Wnt10b/DKK1 during hair regeneration." dans: Experimental dermatology, Vol. 23, Issue 6, pp. 407-13, (2014) (PubMed).

Détails sur CTNNB1

Antigène: CTNNB1 (Catenin (Cadherin-Associated Protein), beta 1, 88kDa (CTNNB1))

Autre désignation: CTNNB1

Sujet:

Synonyms: Catenin beta-1, Beta-catenin, CTNNB1, CTNNB, OK/SW-cl.35, PRO2286

Tissue Specificity: Expressed in several hair follicle cell types: basal and peripheral matrix cells, and cells of the outer and inner root sheaths. Expressed in colon. Present in cortical neurons (at protein level).

Background: Catenins are proteins found in complexes with cadherin cell adhesion molecules of animal cells. The first two catenins that were identified became known as alpha-catenin and beta-catenin. Alpha-catenin can bind to beta-catenin and can also bind actin. Beta-catenin binds the cytoplasmic domain of some cadherins. Beta-catenin is an adherens junction protein. It plays an important role in various aspects of liver biology including liver development (both embryonic and postnatal), liver regeneration following partial hepatectomy. HGF-induced hepatpomegaly, liver zonation, and pathogenesis of liver cancer.

Poids moléculaire: 95 kDa

ID gène: 1499

UniProt: P35222

Pathways: Signalisation WNT, Intracellular Steroid Hormone Receptor Signaling Pathway, Peptide Hormone Metabolism, Regulation of Muscle Cell Differentiation, Cell-Cell Junction Organization, Tube Formation, Maintenance of Protein Location, Signaling Events mediated by VEGFR1 and VEGFR2