GNAI1 anticorps

N° du produit ABIN5699458

Détail du produit anti-GNAI1 anticorps

Antigène: GNAI1 (Guanine Nucleotide Binding Protein (G Protein), alpha Inhibiting Activity Polypeptide 1 (GNAI1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GNAI1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FACS)

Immunogène: guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

human brain tissue were subjected to SDS PAGE followed by western blot with FNab03531(GNAI1 antibody) at dilution of 1:1600

Restrictions: For Research Use only

Stockage

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Date de péremption: 12 months

Détails sur GNAI1

Antigène: GNAI1 (Guanine Nucleotide Binding Protein (G Protein), alpha Inhibiting Activity Polypeptide 1 (GNAI1))

Autre désignation: GNAI1 (GNAI1 Produits)

Synonymes: anticorps AU046200, anticorps Gialpha1, anticorps Gnai-1, anticorps gnai1, anticorps Gi, anticorps BPGTPB, anticorps zgc:63957, anticorps guanine nucleotide binding protein (G protein), alpha inhibiting 1, anticorps G protein subunit alpha i1, anticorps guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 S homeolog, anticorps guanine nucleotide-binding protein G(i) subunit alpha-1, anticorps guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1, anticorps Gnai1, anticorps gnai1.S, anticorps GNAI1, anticorps LOC397505, anticorps gnai1

Sujet: Synonyms: Background:Guanine nucleotide-binding proteins(G proteins) function as transducers downstream of G protein-coupled receptors(GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins(PubMed:8774883, PubMed:18434541). Signaling is mediated via effector proteins, such as adenylate cyclase. Inhibits adenylate cyclase activity, leading to decreased intracellular cAMP levels(By similarity). The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. Required for normal cytokinesis during mitosis(PubMed:17635935).

Poids moléculaire: 40 kDa

ID gène: 2770

UniProt: P63096

Pathways: G-protein mediated Events