AIF anticorps

N° du produit ABIN5700231

Cet anticorps anti-AIF est un anticorps Lapin Polyclonal détectant AIF dans WB, IHC, ELISA, IF et IP. Adapté pour Humain, Souris et Rat.

Aperçu rapide pour AIF anticorps (ABIN5700231)

Antigène: AIF (AIFM1) (Apoptosis-Inducing Factor, Mitochondrion-Associated, 1 (AIFM1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp AIF est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF), Immunoprecipitation (IP)

Détail du produit anti-AIF anticorps

Fonction: AIFM1 antibody

Immunogène: apoptosis-inducing factor, mitochondrion-associated, 1

Isotype: IgG

Information d'application

Indications d'application: WB :1:1000-1:10000,IP:1:1000-1:10000,IF:1:10-1:100,IHC:1:100-400

Commentaires:

Jurkat cells were subjected to SDS PAGE followed by western blot with FNab00235(AIF antibody) at dilution of 1:2000

Restrictions: For Research Use only

Stockage

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur AIF

Antigène: AIF (AIFM1) (Apoptosis-Inducing Factor, Mitochondrion-Associated, 1 (AIFM1))

Autre désignation: AIFM1

Sujet:

Synonyms: Apoptosis-inducing factor 1, mitochondrial|Programmed cell death protein 8|AIFM1|AIF|PDCD8

Background: This gene encodes a flavoprotein essential for nuclear disassembly in apoptotic cells, and it is found in the mitochondrial intermembrane space in healthy cells. Induction of apoptosis results in the translocation of this protein to the nucleus where it affects chromosome condensation and fragmentation. In addition, this gene product induces mitochondria to release the apoptogenic proteins cytochrome c and caspase-9. Mutations in this gene cause combined oxidative phosphorylation deficiency 6 (COXPD6), a severe mitochondrial encephalomyopathy, as well as Cowchock syndrome, also known as X-linked recessive Charcot-Marie-Tooth disease-4 (CMTX-4), a disorder resulting in neuropathy, and axonal and motor-sensory defects with deafness and mental retardation. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 10.

Poids moléculaire: 66kDa

UniProt: O95831

Pathways: Apoptose, Positive Regulation of Endopeptidase Activity, Cell RedoxHomeostasis, Smooth Muscle Cell Migration, L'effet Warburg