HMHA1 anticorps

N° du produit ABIN5702949

Détail du produit anti-HMHA1 anticorps

Antigène: HMHA1 (Histocompatibility (Minor) HA-1 (HMHA1))

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HMHA1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Immunogène: histocompatibility (minor) HA-1

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

Jurkat cells were subjected to SDS PAGE followed by western blot with FNab03935(HMHA1 antibody) at dilution of 1:800

Restrictions: For Research Use only

Stockage

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Date de péremption: 12 months

Détails sur HMHA1

Antigène: HMHA1 (Histocompatibility (Minor) HA-1 (HMHA1))

Autre désignation: HMHA1 (HMHA1 Produits)

Synonymes: anticorps RGD1308662, anticorps MGC80108, anticorps hmha1, anticorps arhgap45, anticorps ha-1, anticorps HMHA1, anticorps DKFZp469A2018, anticorps ARHGAP45, anticorps HA-1, anticorps HLA-HA1, anticorps 6330406L22Rik, anticorps AW539505, anticorps Ha-1, anticorps Rho GTPase activating protein 45, anticorps Rho GTPase activating protein 45 L homeolog, anticorps histocompatibility (minor) HA-1 b, anticorps Arhgap45, anticorps ARHGAP45, anticorps arhgap45.L, anticorps hmha1b, anticorps arhgap45

Sujet: Synonyms:KIAA0223 Background:GTPase activator for the Rho-type GTPases. Precursor of the histocompatibility antigen HA-1. More generally, minor histocompatibility antigens(mHags) refer to immunogenic peptide which, when complexed with MHC, can generate an immune response after recognition by specific T-cells. The peptides are derived from polymorphic intracellular proteins, which are cleaved by normal pathways of antigen processing. The binding of these peptides to MHC class I or class II molecules and its expression on the cell surface can stimulate T-cell responses and thereby trigger graft rejection or graft-versus-host disease(GVHD) after hematopoietic stem cell transplantation from HLA-identical sibling donor. GVHD is a frequent complication after bone marrow transplantation(BMT), due to mismatch of minor histocompatibility antigen in HLA-matched sibling marrow transplants. Specifically, mismatching for mHag HA-1 which is recognized as immunodominant, is shown to be associated with the development of severe GVHD after HLA-identical BMT. HA-1 is presented to the cell surface by MHC class I HLA-A*0201, but also by other HLA-A alleles. This complex specifically elicits donor-cytotoxic T-lymphocyte(CTL) reactivity against hematologic malignancies after treatment by HLA-identical allogenic BMT. It induces cell recognition and lysis by CTL.

Poids moléculaire: 140-150 kDa

ID gène: 23526

UniProt: Q92619