PAN2 anticorps

N° du produit ABIN5704586

Détail du produit anti-PAN2 anticorps

Antigène: PAN2 (PAN2 Poly(A) Specific Ribonuclease Subunit Homolog (PAN2))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PAN2 est non-conjugé

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC)

Immunogène: PAN2 poly(A) specific ribonuclease subunit homolog (S. cerevisiae)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

NIH/3T3 cells were subjected to SDS PAGE followed by western blot with FNab06131(PAN2 antibody) at dilution of 1:300

Restrictions: For Research Use only

Stockage

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Date de péremption: 12 months

Détails sur PAN2

Antigène: PAN2 (PAN2 Poly(A) Specific Ribonuclease Subunit Homolog (PAN2))

Autre désignation: PAN2 (PAN2 Produits)

Synonymes: anticorps USP52, anticorps 1200014O24Rik, anticorps AI047843, anticorps AW742773, anticorps Usp52, anticorps mKIAA0710, anticorps PAN2, anticorps pan2, anticorps PAN2 poly(A) specific ribonuclease subunit, anticorps PAN2 poly(A) specific ribonuclease subunit homolog (S. cerevisiae), anticorps PAN2 poly(A) specific ribonuclease subunit S homeolog, anticorps PAN2, anticorps Pan2, anticorps pan2.S

Sujet: Synonyms:KIAA0710, USP52 Background:Catalytic subunit of the poly(A)-nuclease(PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA when the poly(A) stretch is bound by poly(A)-binding protein(PABP), which is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1.

ID gène: 9924

UniProt: Q504Q3