MMS19 anticorps

N° du produit ABIN5704840

Détail du produit anti-MMS19 anticorps

Antigène: MMS19 (MMS19 Nucleotide Excision Repair Homolog (MMS19))

Reactivité: Humain, Souris, Rat

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp MMS19 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (IHC)

Immunogène: MMS19 nucleotide excision repair homolog (S. cerevisiae)

Isotype: IgG2a

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Date de péremption: 12 months

Détails sur MMS19

Antigène: MMS19 (MMS19 Nucleotide Excision Repair Homolog (MMS19))

Autre désignation: MMS19 (MMS19 Produits)

Synonymes: anticorps MET18, anticorps MMS19L, anticorps hMMS19, anticorps 2410001K24Rik, anticorps 2610042O15Rik, anticorps AI316855, anticorps C79368, anticorps C86341, anticorps Mms19l, anticorps mms19, anticorps mms19l, anticorps MMS19 homolog, cytosolic iron-sulfur assembly component, anticorps MMS19 (MET18 S. cerevisiae), anticorps MMS19 homolog, cytosolic iron-sulfur assembly component L homeolog, anticorps MMS19, anticorps Mms19, anticorps mms19.L

Sujet: Synonyms:MMS19L Background:Key component of the cytosolic iron-sulfur protein assembly(CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins such as ERCC2/XPD, FANCJ and RTEL1, thereby playing a key role in nucleotide excision repair(NER) and RNA polymerase II(POL II) transcription. As part of the mitotic spindle-associated MMXD complex, plays a role in chromosome segregation, probably by facilitating iron-sulfur cluster assembly into ERCC2/XPD. Indirectly acts as a transcriptional coactivator of estrogen receptor(ER), via its role in iron-sulfur insertion into some component of the TFIIH-machinery.

Poids moléculaire: 103 kDa

ID gène: 64210

UniProt: Q96T76

Pathways: Nuclear Hormone Receptor Binding