SIAH2 anticorps

N° du produit ABIN5705475

Détail du produit anti-SIAH2 anticorps

Antigène: SIAH2 (Siah E3 Ubiquitin Protein Ligase 2 (SIAH2))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SIAH2 est non-conjugé

Application: Western Blotting (WB), ELISA

Immunogène: seven in absentia homolog 2 (Drosophila)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Date de péremption: 12 months

Détails sur SIAH2

Antigène: SIAH2 (Siah E3 Ubiquitin Protein Ligase 2 (SIAH2))

Autre désignation: SIAH2 (SIAH2 Produits)

Synonymes: anticorps hSiah2, anticorps Xsiah-2, anticorps siah2-A, anticorps xsiah2, anticorps AA415433, anticorps Sinh2, anticorps siah E3 ubiquitin protein ligase 2, anticorps siah E3 ubiquitin protein ligase 2 L homeolog, anticorps seven in absentia 2, anticorps SIAH2, anticorps siah2.L, anticorps Siah2

Sujet: Synonyms: Background:E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates E3 ubiquitin ligase activity either through direct binding to substrates or by functioning as the essential RING domain subunit of larger E3 complexes. Triggers the ubiquitin-mediated degradation of many substrates, including proteins involved in transcription regulation(POU2AF1, PML, NCOR1), a cell surface receptor(DCC), an antiapoptotic protein(BAG1), and a protein involved in synaptic vesicle function in neurons(SYP). Mediates ubiquitination and proteasomal degradation of DYRK2 in response to hypoxia. It is thereby involved in apoptosis, tumor suppression, cell cycle, transcription and signaling processes. Has some overlapping function with SIAH1. Triggers the ubiquitin-mediated degradation of TRAF2, whereas SIAH1 does not. Promotes monoubiquitination of SNCA.

ID gène: 6478

UniProt: O43255