Nth Endonuclease III-Like 1 (NTHL1) anticorps

N° du produit ABIN5706093

Détail du produit

Antigène: Nth Endonuclease III-Like 1 (NTHL1)

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Inconjugué

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Immunogène: nth endonuclease III-like 1 (E. coli)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

Y79 cells were subjected to SDS PAGE followed by western blot with FNab05883(NTHL1 antibody) at dilution of 1:1000

Restrictions: For Research Use only

Stockage

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Date de péremption: 12 months

Détail du antigène

Antigène: Nth Endonuclease III-Like 1 (NTHL1)

Autre désignation: NTHL1 (NTHL1 Produits)

Synonymes: anticorps psmc3, anticorps psmc3-a, anticorps nth-like DNA glycosylase 1 S homeolog, anticorps nthl1.S

Sujet: Synonyms:NTH1, OCTS3 Background:Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic(AP) lyase function that catalyzes the first step in base excision repair(BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines. Has also 8-oxo-7,8-dihydroguanine(8-oxoG) DNA glycosylase activity. Acts preferentially on DNA damage opposite guanine residues in DNA. Is able to process lesions in nucleosomes without requiring or inducing nucleosome disruption.

Poids moléculaire: 34 kDa

ID gène: 4913

UniProt: P78549