KCNJ13 anticorps (AA 200-250)

N° du produit ABIN571906

Détail du produit anti-KCNJ13 anticorps

Antigène: KCNJ13 (Potassium Inwardly-Rectifying Channel, Subfamily J, Member 13 (KCNJ13))

Épitope: AA 200-250

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp KCNJ13 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Specificité: Specific for KCNJ13.

Réactivité croisée: Humain

Réactivité croisée (Details): Other species not yet tested but expected to work in rat and mouse.

Purification: IgG

Immunogène: A synthetic peptide from AA 200-250 of human KCNJ13 conjugated to an immunogenic carrier protein was used as the antigen. The peptide shares 95% identity with rat and mouse sequences.

Isotype: IgG

Information d'application

Indications d'application: IHC, WB. A concentration of 10-50 μg,ml is recommended. The optimal concentration should be determined by the end user. Not yet tested in other applications.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Reconstitute in 100 μL of sterile water. Centrifuge to remove any insoluble material.

Conseil sur la manipulation: Avoid freeze and thaw cycles.

Stock: 4 °C/-20 °C

Stockage commentaire: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Date de péremption: 12 months

Détails sur KCNJ13

Antigène: KCNJ13 (Potassium Inwardly-Rectifying Channel, Subfamily J, Member 13 (KCNJ13))

Autre désignation: KCNJ13 (KCNJ13 Produits)

Synonymes: anticorps kir7.1, anticorps KIR1.4, anticorps KIR7.1, anticorps LCA16, anticorps SVD, anticorps Kir7.1, anticorps potassium voltage-gated channel subfamily J member 13, anticorps potassium inwardly-rectifying channel, subfamily J, member 13, anticorps potassium channel, inwardly rectifying subfamily J, member 13, anticorps KCNJ13, anticorps kcnj13, anticorps Kcnj13

Sujet: FUNCTION: Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium, as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ13 has a very low single channel conductance, low sensitivity to block by external barium and cesium, and no dependence of its inward rectification properties on the internal blocking particle magnesium. Tissue specificity: Predominantly expressed in small intestine. Expression is also detected in stomach, kidney, and all central nervous system regions tested with the exception of spinal cord. Subcellular location: Membrane, Multi-pass membrane protein. Involvement in disease: Defects in KCNJ13 are the cause of snowflake vitreoretinal degeneration (SVD). SVD is a developmental and progressive hereditary eye disorder that affects multiple tissues within the eye. Diagnostic features of SVD include fibrillar degeneration of the vitreous humor, early-onset cataract, minute crystalline deposits in the neurosensory retina, and retinal detachment.,Inward Rectifier,Inward rectifier potassium channel 13, Potassium channel, inwardly rectifying subfamily J member 13, Inward rectifier K(+) channel Kir7.1

UniProt: O60928