SGK1 anticorps (Ser422)

N° du produit ABIN5961255

L’anticorps Lapin Polyclonal anti-SGK1 a été validé pour WB, ELISA et IHC (p). Il convient pour détecter SGK1 dans des échantillons de Humain, Souris et Rat.

Aperçu rapide pour SGK1 anticorps (Ser422) (ABIN5961255)

Antigène: SGK1 (serum/glucocorticoid Regulated Kinase 1 (SGK1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SGK1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-SGK1 anticorps

Épitope: Ser422

Specificité: OTTHUMP00000017247,Serine/threonine protein kinase SGK,Serine/threonine protein kinase Sgk1,Serine/threonine-protein kinase Sgk1,Serum and glucocorticoid regulated kinase,Serum/glucocorticoid regulated kinase 1,Serum/glucocorticoid regulated kinase,Serum/glucocorticoid-regulated kinase 1,SGK 1,SGK,SGK1,Sgk1 variant i3,SGK1

Purification: Affinity purification

Immunogène: Synthesized peptide derived from human SGK1 around the non-phosphorylation site of Ser422.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000, IHC 1:100-1:300, ELISA 1:5000

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 0.5 % BSA and 50 % glycerol,  pH 7.4

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur SGK1

Antigène: SGK1 (serum/glucocorticoid Regulated Kinase 1 (SGK1))

Autre désignation: SGK1

Sujet: Protein kinase that plays an important role in cellular stress response. Activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability and renal sodium excretion. Sustained high levels and activity may contribute to conditions such as hypertension and diabetic nephropathy. Mediates cell survival signals, phosphorylates and negatively regulates pro-apoptotic FOXO3A. Phosphorylates NEDD4L, which leads to its inactivation and to the subsequent activation of various channels and transporters such as ENaC, KCNA3/Kv1.3 or EAAT1. Isoform 2 exhibited a greater effect on cell plasma membrane expression of ENaC and Na(+) transport than isoform 1.

Poids moléculaire: 49kDa

ID gène: 6446

UniProt: O00141

Pathways: Signalisation MAPK, Signalisation Notch, Steroid Hormone Mediated Signaling Pathway