ABCC2 anticorps (AA 180-315)

N° du produit ABIN6136357

Détail du produit anti-ABCC2 anticorps

Antigène: ABCC2 (ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 2 (ABCC2))

Épitope: AA 180-315

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ABCC2 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF)

Séquence: IFSAFSENNE SSNNPSSIAS FLSSITYSWY DSIILKGYKR PLTLEDVWEV DEEMKTKTLV SKFETHMKRE LQKARRALQR RQEKSSQQNS GARLPGLNKN QSQSQDALVL EDVEKKKKKS GTKKDVPKSW LMKALF

Réactivité croisée: Humain, Souris, Rat

Attributs du produit: Polyclonal Antibodies

Purification: Affinity purification

Immunogène: Recombinant fusion protein containing a sequence corresponding to amino acids 180-315 of human MRP2/ABCC2 (NP_000383.1).

Isotype: IgG

Information d'application

Indications d'application: WB,1:500 - 1:2000,IF,1:50 - 1:200

Commentaires:

HIGH QUALITY

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur ABCC2

Antigène: ABCC2 (ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 2 (ABCC2))

Autre désignation: ABCC2 (ABCC2 Produits)

Synonymes: anticorps ABC30, anticorps CMOAT, anticorps DJS, anticorps MRP2, anticorps cMRP, anticorps AI173996, anticorps Abc30, anticorps Cmoat, anticorps Mrp2, anticorps ATP binding cassette subfamily C member 2, anticorps ATP-binding cassette, sub-family C (CFTR/MRP), member 2, anticorps ABCC2, anticorps Abcc2

Sujet: The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is expressed in the canalicular (apical) part of the hepatocyte and functions in biliary transport. Substrates include anticancer drugs such as vinblastine, therefore, this protein appears to contribute to drug resistance in mammalian cells. Several different mutations in this gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia.,ABCC2,ABC30,CMOAT,DJS,MRP2,cMRP,Cancer,Drug resistance,MRP-related proteins,Signal Transduction,Endocrine & Metabolism,ABCC2

Poids moléculaire: 174 kDa

ID gène: 1244

UniProt: Q92887

Pathways: Hormone Transport