CBFB anticorps (AA 1-182)

N° du produit ABIN6138000

Détail du produit anti-CBFB anticorps

Antigène: CBFB (Core-Binding Factor, beta Subunit (CBFB))

Épitope: AA 1-182

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CBFB est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Séquence: MPRVVPDQRS KFENEEFFRK LSRECEIKYT GFRDRPHEER QARFQNACRD GRSEIAFVAT GTNLSLQFFP ASWQGEQRQT PSREYVDLER EAGKVYLKAP MILNGVCVIW KGWIDLQRLD GMGCLEFDEE RAQQEDALAQ QAFEEARRRT REFEDRDRSH REEMEVRVSQ LLAVTGKKTT RP

Réactivité croisée: Humain, Souris

Attributs du produit: Polyclonal Antibodies

Purification: Affinity purification

Immunogène: Recombinant fusion protein containing a sequence corresponding to amino acids 1-182 of human CBFB (NP_001746.1).

Isotype: IgG

Information d'application

Indications d'application: WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200

Commentaires:

HIGH QUALITY

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur CBFB

Antigène: CBFB (Core-Binding Factor, beta Subunit (CBFB))

Autre désignation: CBFB (CBFB Produits)

Synonymes: anticorps PEBP2B, anticorps Cbfb, anticorps pebp2b, anticorps Pebp2, anticorps CBFB, anticorps unp1266, anticorps cbf-beta, anticorps cbfbeta, anticorps pea2-beta, anticorps pebp2-beta, anticorps AI893578, anticorps PEA2, anticorps PEBP2b, anticorps Pebpb2, anticorps core-binding factor beta subunit, anticorps core binding factor beta subunit, anticorps core-binding factor, beta subunit, anticorps core-binding factor, beta subunit S homeolog, anticorps core binding factor beta, anticorps CBFB, anticorps Cbfb, anticorps cbfb, anticorps cbfb.S

Sujet: The protein encoded by this gene is the beta subunit of a heterodimeric core-binding transcription factor belonging to the PEBP2/CBF transcription factor family which master-regulates a host of genes specific to hematopoiesis (e.g., RUNX1) and osteogenesis (e.g., RUNX2). The beta subunit is a non-DNA binding regulatory subunit, it allosterically enhances DNA binding by alpha subunit as the complex binds to the core site of various enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers and GM-CSF promoters. Alternative splicing generates two mRNA variants, each encoding a distinct carboxyl terminus. In some cases, a pericentric inversion of chromosome 16 [inv(16)(p13q22)] produces a chimeric transcript consisting of the N terminus of core-binding factor beta in a fusion with the C-terminal portion of the smooth muscle myosin heavy chain 11. This chromosomal rearrangement is associated with acute myeloid leukemia of the M4Eo subtype. Two transcript variants encoding different isoforms have been found for this gene.,CBFB,PEBP2B,Epigenetics & Nuclear Signaling,CBFB

Poids moléculaire: 21 kDa

ID gène: 865

UniProt: Q13951

Pathways: Regulation of Lipid Metabolism by PPARalpha