NPC1L1 anticorps (AA 1030-1100)

N° du produit ABIN6144760

Détail du produit anti-NPC1L1 anticorps

Antigène: NPC1L1 (NPC1 (Niemann-Pick Disease, Type C1, Gene)-Like 1 (NPC1L1))

Épitope: AA 1030-1100

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NPC1L1 est non-conjugé

Application: Western Blotting (WB)

Séquence: AAYSTSVNLT SDGQVLASRF MAYHKPLKNS QDYTEALRAA RELAANITAD LRKVPGTDPA FEVFPYTITN V

Réactivité croisée: Humain

Attributs du produit: Polyclonal Antibodies

Immunogène: Recombinant fusion protein containing a sequence corresponding to amino acids 1030-1100 of human NPC1L1 (NP_001095118.1).

Isotype: IgG

Information d'application

Indications d'application: WB,1:1000 - 1:4000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur NPC1L1

Antigène: NPC1L1 (NPC1 (Niemann-Pick Disease, Type C1, Gene)-Like 1 (NPC1L1))

Autre désignation: NPC1L1 (NPC1L1 Produits)

Synonymes: anticorps NPC1L1, anticorps 9130221N23Rik, anticorps Gm243, anticorps NPC11L1, anticorps NPC1 like intracellular cholesterol transporter 1, anticorps NPC1 like 1, anticorps NPC1-like 1, anticorps NPC1L1, anticorps npc1l1, anticorps Npc1l1

Sujet: The protein encoded by this gene is a multi-pass membrane protein. It contains a conserved N-terminal Niemann-Pick C1 (NPC1) domain and a putative sterol-sensing domain (SSD) which includes a YQRL motif functioning as a plasma membrane to trans-Golgi network transport signal in other proteins. This protein takes up free cholesterol into cells through vesicular endocytosis and plays a critical role in the absorption of intestinal cholesterol. It also has the ability to transport alpha-tocopherol (vitamin E). The drug ezetimibe targets this protein and inhibits the absorption of intestinal cholesterol and alpha-tocopherol. In addition, this protein may play a critical role in regulating lipid metabolism. Polymorphic variations in this gene are associated with plasma total cholesterol and low-density lipoprotein cholesterol (LDL-C) levels and coronary heart disease (CHD) risk. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.,NPC1L1,NPC11L1,Cancer,Signal Transduction,Endocrine & Metabolism,Lipid Metabolism,Cholesterol Metabolism,Neuroscience,Cardiovascular,Heart,Lipids,Cardiovascular diseases,Heart disease,NPC1L1

Poids moléculaire: 79 kDa/140 kDa/145 kDa/148 kDa

ID gène: 29881

UniProt: Q9UHC9