FASL anticorps

N° du produit ABIN614577

L’anticorps Hamster Monoclonal anti-FASL a été validé pour FACS. Il convient pour détecter FASL dans des échantillons de Souris et Rat.

Aperçu rapide pour FASL anticorps (ABIN614577)

Antigène: FASL (Fas Ligand (TNF Superfamily, Member 6) (FASL))

Reactivité: Souris, Rat

Hôte: Hamster

Clonalité: Monoclonal

Conjugué: Cet anticorp FASL est non-conjugé

Application: Flow Cytometry (FACS)

Clone: MFL4

Détail du produit anti-FASL anticorps

Specificité: Recognizes both Mouse and Rat CD178. Clone MFL4 is reported to block CD178/CD95 induced apoptosis. We recommend the use of AM20860LE-N for functional studies.

Purification: Affinity Chromatography on Protein G

Immunogène: B6 Mouse FasL/BHK cells

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.09 % Sodium Azide as preservative.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur FASL

Antigène: FASL (Fas Ligand (TNF Superfamily, Member 6) (FASL))

Autre désignation: CD178 / Fas Ligand

Sujet: CD178, otherwise known as Fas Ligand/ CD95L, a 40 kDa type II transmembrane glycoprotein and member of the TNF/NGF superfamily, expressed by activated T cells and NK cells, which can be induced on a variety of cells by radiation, heat shock, chemotherapeutic agents and viral infection. CD178 acts as a key effector of cytotoxicity and in the regulation of immune responses. The binding of CD178 to its receptor CD95 (Fas), induces Fas-mediated apoptosis of target cells, and may be involved in the induction of peripheral tolerance and neutrophil chemotaxis. The binding of decoy receptor 3 (DcR3) to CD178 has been shown to inhibit CD178-mediated apoptosis.Synonyms: APT1LG1, APTL, Apoptosis antigen ligand, CD95L protein, FASL, FASLG, Fas antigen ligand, TNFSF6, Tumor necrosis factor ligand superfamily member 6

ID gène: 14103

NCBI Accession: NP_034307

UniProt: P41047

Pathways: Apoptose, EGFR Signaling Pathway, Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity