PKC zeta anticorps (AA 453-592)

N° du produit ABIN6146211

Détail du produit anti-PKC zeta anticorps

Antigène: PKC zeta (PRKCZ) (Protein Kinase C, zeta (PRKCZ))

Épitope: AA 453-592

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PKC zeta est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF)

Séquence: IITDNPDMNT EDYLFQVILE KPIRIPRFLS VKASHVLKGF LNKDPKERLG CRPQTGFSDI KSHAFFRSID WDLLEKKQAL PPFQPQITDD YGLDNFDTQF TSEPVQLTPD DEDAIKRIDQ SEFEGFEYIN PLLLSTEESV

Réactivité croisée: Humain, Souris, Rat

Attributs du produit: Polyclonal Antibodies

Immunogène: Recombinant fusion protein containing a sequence corresponding to amino acids 453-592 of human PKC zeta (NP_002735.3).

Isotype: IgG

Information d'application

Indications d'application: WB,1:500 - 1:1000,IF,1:50 - 1:200

Commentaires:

HIGH QUALITY

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur PKC zeta

Antigène: PKC zeta (PRKCZ) (Protein Kinase C, zeta (PRKCZ))

Autre désignation: PRKCZ (PRKCZ Produits)

Sujet: Protein kinase C (PKC) zeta is a member of the PKC family of serine/threonine kinases which are involved in a variety of cellular processes such as proliferation, differentiation and secretion. Unlike the classical PKC isoenzymes which are calcium-dependent, PKC zeta exhibits a kinase activity which is independent of calcium and diacylglycerol but not of phosphatidylserine. Furthermore, it is insensitive to typical PKC inhibitors and cannot be activated by phorbol ester. Unlike the classical PKC isoenzymes, it has only a single zinc finger module. These structural and biochemical properties indicate that the zeta subspecies is related to, but distinct from other isoenzymes of PKC. Alternative splicing results in multiple transcript variants encoding different isoforms.,PRKCZ,PKC-ZETA,PKC2,Signal Transduction,G protein signaling,G2/M DNA Damage Checkpoint,Kinase,Serine/threonine kinases,Phospholipase Signaling Pathway,Protein Kinase C Signaling Pathway,ErbB-HER Signaling Pathway,MAPK-Erk Signaling Pathway,Cell Biology & Developmental Biology,Apoptosis,Mitochondrial Control of Apoptosis,Inhibition of Apoptosis,TGF-b-Smad Signaling Pathway,Endocrine & Metabolism,Insulin Receptor Signaling Pathway,Immunology & Inflammation,B Cell Receptor Signaling Pathway,NF-kB Signaling Pathway,PRKCZ

Poids moléculaire: 46 kDa/56 kDa/67 kDa

ID gène: 5590

UniProt: Q05513

Pathways: Signalisation NF-kappaB, Signalisation RTK, Myometrial Relaxation and Contraction, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Synaptic Membrane, Production of Molecular Mediator of Immune Response, CXCR4-mediated Signaling Events, Thromboxane A2 Receptor Signaling