SMAD4 anticorps (AA 160-450)

N° du produit ABIN6148088

Cet anticorps Lapin Polyclonal détecte spécifiquement SMAD4 dans WB et IHC. Il présente une réactivité envers Humain.

Aperçu rapide pour SMAD4 anticorps (AA 160-450) (ABIN6148088)

Antigène: SMAD4 (SMAD Family Member 4 (SMAD4))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SMAD4 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-SMAD4 anticorps

Épitope: AA 160-450

Séquence: DEYVHDFEGQ PSLSTEGHSI QTIQHPPSNR ASTETYSTPA LLAPSESNAT STANFPNIPV ASTSQPASIL GGSHSEGLLQ IASGPQPGQQ QNGFTGQPAT YHHNSTTTWT GSRTAPYTPN LPHHQNGHLQ HHPPMPPHPG HYWPVHNELA FQPPISNHPA PEYWCSIAYF EMDVQVGETF KVPSSCPIVT VDGYVDPSGG DRFCLGQLSN VHRTEAIERA RLHIGKGVQL ECKGEGDVWV RCLSDHAVFV QSYYLDREAG RAPGDAVHKI YPSAYIKVFD LRQCHRQMQQ Q

Réactivité croisée: Humain, Souris, Rat

Attributs du produit: Polyclonal Antibodies

Immunogène: Recombinant fusion protein containing a sequence corresponding to amino acids 160-450 of human Smad4 (NP_005350.1).

Isotype: IgG

Information d'application

Indications d'application: WB,1:500 - 1:2000,IHC,1:50 - 1:200

Commentaires:

HIGH QUALITY

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur SMAD4

Antigène: SMAD4 (SMAD Family Member 4 (SMAD4))

Autre désignation: SMAD4

Sujet: This gene encodes a member of the Smad family of signal transduction proteins. Smad proteins are phosphorylated and activated by transmembrane serine-threonine receptor kinases in response to TGF-beta signaling. The product of this gene forms homomeric complexes and heteromeric complexes with other activated Smad proteins, which then accumulate in the nucleus and regulate the transcription of target genes. This protein binds to DNA and recognizes an 8-bp palindromic sequence (GTCTAGAC) called the Smad-binding element (SBE). The Smad proteins are subject to complex regulation by post-translational modifications. Mutations or deletions in this gene have been shown to result in pancreatic cancer, juvenile polyposis syndrome, and hereditary hemorrhagic telangiectasia syndrome.,DPC4,JIP,MADH4,MYHRS,Smad4,SMAD4,Epigenetics & Nuclear Signaling,Transcription Factors,Cancer,Tumor suppressors,Signal Transduction,MAPK-JNK Signaling Pathway,Cell Biology & Developmental Biology,Apoptosis,Cell Cycle,G1/S Checkpoint,TGF-b-Smad Signaling Pathway,ESC Pluripotency and Differentiation,Endocrine & Metabolism,Stem Cells,Cardiovascular,Hypoxia,Heart,Cardiogenesis,Hypertrophy,SMADs,SMAD4

Poids moléculaire: 60 kDa

ID gène: 4089

UniProt: Q13485

Pathways: Cycle Cellulaire, Chromatin Binding, Autophagy