KCNJ11 anticorps (Internal Region)

N° du produit ABIN614945

Détail du produit anti-KCNJ11 anticorps

Antigène: KCNJ11 (Potassium Inwardly-Rectifying Channel, Subfamily J, Member 11 (KCNJ11))

Épitope: Internal Region

Reactivité: Humain, Souris, Rat, Chien

Hôte: Chèvre

Clonalité: Polyclonal

Conjugué: Cet anticorp KCNJ11 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Séquence: ERRARFVSKK GNC

Réactivité croisée (Details): Species reactivity (expected):Dog, Mouse, RatSpecies reactivity (tested):Human

Purification: Immunoaffinity chromatography

Immunogène: Synthetic peptide from an internal region of human Kcnj11 Genename: KCNJ11

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: Tris saline buffer, pH 7.3, 0.5 % BSA, 0.02 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.

Détails sur KCNJ11

Antigène: KCNJ11 (Potassium Inwardly-Rectifying Channel, Subfamily J, Member 11 (KCNJ11))

Autre désignation: KCNJ11 (KCNJ11 Produits)

Synonymes: anticorps kir6.2, anticorps Kir6.2, anticorps mBIR, anticorps BIR, anticorps HHF2, anticorps IKATP, anticorps KIR6.2, anticorps PHHI, anticorps TNDM3, anticorps potassium voltage-gated channel subfamily J member 11, anticorps potassium inwardly-rectifying channel, subfamily J, member 11, anticorps potassium inwardly rectifying channel, subfamily J, member 11, anticorps KCNJ11, anticorps kcnj11, anticorps Kcnj11

Sujet: Kir6.2/Kcnj11, an ATP sensitive inwardly-rectifying potassium channel, was originally isolated from an insulinoma library. Actual conductance requires association with the sulfonylurea receptor. This receptor is inhibited by sulfonylureas and activated by diazoxide. Mutations in the KNCJ11 gene are found in patients with permanent diabetes mellitus of infancy and hyperinsulinemic hypoglycemia. It is thought that this channel couples metabolism to membrane electrical events fibringing about insulin secretion.Synonyms: ATP-sensitive inward rectifier potassium channel 11, IKATP, Inward rectifier K+ channel Kir6.2, KCNJ11, Potassium channel, inwardly rectifying subfamily J member 11

ID gène: 9606

UniProt: Q14654

Pathways: Negative Regulation of Hormone Secretion