APOBEC3G anticorps (C-Term)

N° du produit ABIN615432

Détail du produit anti-APOBEC3G anticorps

Antigène: APOBEC3G (Apolipoprotein B mRNA Editing Enzyme, Catalytic Polypeptide-Like 3G (APOBEC3G))

Épitope: C-Term

Reactivité: Humain

Hôte: Chèvre

Clonalité: Polyclonal

Conjugué: Cet anticorp APOBEC3G est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Séquence: C-DEHSQDLSGR LR

Specificité: This antibody detects APOBEC3G (C-term).

Réactivité croisée (Details): Species reactivity (tested):Human

Purification: Immunoaffinity Chromatography

Immunogène: Synthetic peptide from the C Terminus of the protein sequence according to NP_068594.1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: Tris saline, 0.02 % sodium azide, pH 7.3, 0.5 % BSA

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Détails sur APOBEC3G

Antigène: APOBEC3G (Apolipoprotein B mRNA Editing Enzyme, Catalytic Polypeptide-Like 3G (APOBEC3G))

Autre désignation: APOBEC3G (APOBEC3G Produits)

Synonymes: anticorps A3G, anticorps ARCD, anticorps ARP-9, anticorps ARP9, anticorps CEM-15, anticorps CEM15, anticorps bK150C2.7, anticorps dJ494G10.1, anticorps apolipoprotein B mRNA editing enzyme catalytic subunit 3G, anticorps APOBEC3G

Sujet: The Apoliprotein B mRNA-editing, enzyme-catalytic, polypeptide-like (APOBEC) 3 is a multi-isoform member of the cytidine deaminase family of enzymes that act on monomeric nucleoside and nucleotide substrates. Similar to TRIM5a which targets incoming retroviral capsids, APOBEC3 plays a major role in cellular defense against retroviral infection as at least two isoforms, APOBEC3G and to a lesser extent APOBEC3F, can be incorporated HIV-1 virions and induce hypermutation in the newly synthesized viral DNA and thus destabilize the viral genome. This innate mechanism of retroviral resistance is counteracted by the HIV-1 Vif protein by inducing the ubiquitization and degradation of APOBEC3G, a single amino acid substitution (D128K) blocks APOBEC3G depletion without affecting its inhibitory activity.Synonyms: APOBEC-3G, APOBEC-related cytidine deaminase, ARCD, ARP9, CEM15, DNA dC->dU-editing enzyme APOBEC-3G, MDS019

ID gène: 60489

NCBI Accession: NP_068594

UniProt: Q9HC16