MAPK6 anticorps (pSer189)

N° du produit ABIN6241031

Cet anticorps Lapin Polyclonal détecte spécifiquement MAPK6 dans IHC (p). Il présente une réactivité envers Humain et a été mentionné dans 5+ publications.

Aperçu rapide pour MAPK6 anticorps (pSer189) (ABIN6241031)

Antigène: MAPK6 (Mitogen-Activated Protein Kinase 6 (MAPK6))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MAPK6 est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB5800

Détail du produit anti-MAPK6 anticorps

Épitope: pSer189

Homologie: C, M, Rat

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This Phospho-ERK3-S189 antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S189 of human ERK3.

Isotype: Ig Fraction

Information d'application

Indications d'application: IHC-P: 1:50~100

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Références pour anticorps anti-MAPK6 (ABIN6241031)

Wang, Kong, Lin, Li, Izumiya, Ding, Zhang, Hu, Yang, Gao, Lam, Li: "A versatile nanoplatform for synergistic combination therapy to treat human esophageal cancer." dans: Acta pharmacologica Sinica, Vol. 38, Issue 6, pp. 931-942, (2018) (PubMed).

Perander, Al-Mahdi, Jensen, Nunn, Kildalsen, Johansen, Gabrielsen, Keyse, Seternes: "Regulation of atypical MAP kinases ERK3 and ERK4 by the phosphatase DUSP2." dans: Scientific reports, Vol. 7, pp. 43471, (2017) (PubMed).

De la Mota-Peynado, Chernoff, Beeser: "Identification of the atypical MAPK Erk3 as a novel substrate for p21-activated kinase (Pak) activity." dans: The Journal of biological chemistry, Vol. 286, Issue 15, pp. 13603-11, (2011) (PubMed).

Purcell, Wilkins, York, Saba-El-Leil, Meloche, Robbins, Molkentin: "Genetic inhibition of cardiac ERK1/2 promotes stress-induced apoptosis and heart failure but has no effect on hypertrophy in vivo." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, Issue 35, pp. 14074-9, (2007) (PubMed).

Sakai, Yamauchi, Kawano: "[Measurement of internal voids in impression material using a digital image analyzer. Part 1. Investigation of the measurement system of a digital image analyzer]." dans: Nihon Hotetsu Shika Gakkai zasshi, Vol. 32, Issue 1, pp. 28-36, (1989) (PubMed).

Détails sur MAPK6

Antigène: MAPK6 (Mitogen-Activated Protein Kinase 6 (MAPK6))

Autre désignation: ERK3

Sujet: ERK3 is a member of the Ser/Thr protein kinase family, and is most closely related to mitogen-activated protein kinases (MAP kinases). MAP kinases also known as extracellular signal-regulated kinases (ERKs), are activated through protein phosphorylation cascades and act as integration points for multiple biochemical signals. This kinase is localized in the nucleus, and has been reported to be activated in fibroblasts upon treatment with serum or phorbol esters.

Poids moléculaire: 82681

NCBI Accession: NP_002739

UniProt: Q16659

Pathways: Signalisation MAPK, Neurotrophin Signaling Pathway, Regulation of Muscle Cell Differentiation, Hepatitis C