SMARCE1 anticorps (C-Term)

N° du produit ABIN6242198

Détail du produit anti-SMARCE1 anticorps

Antigène: SMARCE1 (SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily E, Member 1 (SMARCE1))

Épitope: AA 327-361, C-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SMARCE1 est non-conjugé

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This SMARCE1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 327-361 amino acids from the C-terminal region of human SMARCE1.

Clone: RB51409

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Détails sur SMARCE1

Antigène: SMARCE1 (SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily E, Member 1 (SMARCE1))

Autre désignation: SMARCE1 (SMARCE1 Produits)

Synonymes: anticorps BAF57, anticorps XBaf57, anticorps MGC52696, anticorps MGC69429, anticorps MGC81726, anticorps SMARCE1, anticorps DKFZp459O2235, anticorps fb54d11, anticorps wu:fb33d02, anticorps wu:fb54d11, anticorps Baf57, anticorps 2810417B20Rik, anticorps 5830412H02Rik, anticorps 9030408N19Rik, anticorps Baf27, anticorps RGD1304726, anticorps SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1, anticorps SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 L homeolog, anticorps smarce1, anticorps SMARCE1, anticorps smarce1.L, anticorps Smarce1

Sujet: Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Required for the coactivation of estrogen responsive promoters by Swi/Snf complexes and the SRC/p160 family of histone acetyltransferases (HATs). Also specifically interacts with the CoREST corepressor resulting in repression of neuronal specific gene promoters in non-neuronal cells. Also involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene.

Poids moléculaire: 46649

UniProt: Q969G3

Pathways: Chromatin Binding