WWP2 anticorps (N-Term)

N° du produit ABIN6242488

Détail du produit anti-WWP2 anticorps

Antigène: WWP2 (WW Domain Containing E3 Ubiquitin Protein Ligase 2 (WWP2))

Épitope: AA 218-252, N-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp WWP2 est non-conjugé

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This WWP2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 218-252 amino acids from the N-terminal region of human WWP2.

Clone: RB51426

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Détails sur WWP2

Antigène: WWP2 (WW Domain Containing E3 Ubiquitin Protein Ligase 2 (WWP2))

Autre désignation: WWP2 (WWP2 Produits)

Synonymes: anticorps aip2, anticorps wwp2-like, anticorps id:ibd1121, anticorps wu:fo87e10, anticorps zgc:154036, anticorps AIP2, anticorps WWp2-like, anticorps 1300010O06Rik, anticorps AA690238, anticorps AW554328, anticorps WW domain containing E3 ubiquitin protein ligase 2, anticorps WWP2, anticorps wwp2, anticorps Wwp2

Sujet: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Polyubiquitinates POU5F1 by 'Lys-63'-linked conjugation and promotes it to proteasomal degradation, in embryonic stem cells (ESCs) the ubiquitination is proposed to regulate POU5F1 protein level. Ubiquitinates EGR2 and promotes it to proteasomal degradation, in T-cells the ubiquitination inhibits activation- induced cell death. Ubiquitinates SLC11A2, the ubiquitination is enhanced by presence of NDFIP1 and NDFIP2. Ubiquitinates RPB1 and promotes it to proteasomal degradation.

Poids moléculaire: 98912

UniProt: O00308

Pathways: Negative Regulation of Transporter Activity