This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunogène
This HIST1H2BM antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 10-44 amino acids from the N-terminal region of human HIST1H2BM.
anticorps H2B/e, anticorps H2BFE, anticorps dJ160A22.3, anticorps H2b-291b, anticorps histone cluster 1 H2B family member m, anticorps histone cluster 1, H2bm, anticorps HIST1H2BM, anticorps Hist1h2bm
Sujet
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.