PAFAH1B1 anticorps (N-Term)

N° du produit ABIN6243934

Détail du produit anti-PAFAH1B1 anticorps

Antigène: PAFAH1B1 (Platelet-Activating Factor Acetylhydrolase 1b, Regulatory Subunit 1 (45kDa) (PAFAH1B1))

Épitope: AA 76-110, N-Term

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PAFAH1B1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Homologie: B, C, Pr, Pig

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This PAFAH1B1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 76-110 amino acids from the N-terminal region of human PAFAH1B1.

Clone: RB50845

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000. IHC-P: 1:25

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Détails sur PAFAH1B1

Antigène: PAFAH1B1 (Platelet-Activating Factor Acetylhydrolase 1b, Regulatory Subunit 1 (45kDa) (PAFAH1B1))

Autre désignation: PAFAH1B1 (PAFAH1B1 Produits)

Synonymes: anticorps LIS1, anticorps LIS2, anticorps MDCR, anticorps MDS, anticorps PAFAH, anticorps LIS-1, anticorps Lis1, anticorps MMS10-U, anticorps Mdsh, anticorps Ms10u, anticorps Pafaha, anticorps lis2, anticorps mdcr, anticorps mds, anticorps pafah, anticorps pafah1b1-b, anticorps PAFAHA, anticorps Lis1a, anticorps platelet activating factor acetylhydrolase 1b regulatory subunit 1, anticorps platelet-activating factor acetylhydrolase, isoform 1b, subunit 1, anticorps platelet-activating factor acetylhydrolase 1b, regulatory subunit 1, anticorps platelet activating factor acetylhydrolase 1b regulatory subunit 1 L homeolog, anticorps platelet-activating factor acetylhydrolase 1b, regulatory subunit 1a, anticorps platelet-activating factor acetylhydrolase 1b, regulatory subunit 1b, anticorps PAFAH1B1, anticorps Pafah1b1, anticorps pafah1b1.L, anticorps pafah1b1a, anticorps pafah1b1b

Sujet: Required for proper activation of Rho GTPases and actin polymerization at the leading edge of locomoting cerebellar neurons and postmigratory hippocampal neurons in response to calcium influx triggered via NMDA receptors. Non-catalytic subunit of an acetylhydrolase complex which inactivates platelet- activating factor (PAF) by removing the acetyl group at the SN-2 position (By similarity). Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Neuronal migration involves a process called nucleokinesis, whereby migrating cells extend an anterior process into which the nucleus subsequently translocates. During nucleokinesis dynein at the nuclear surface may translocate the nucleus towards the centrosome by exerting force on centrosomal microtubules. May also play a role in other forms of cell locomotion including the migration of fibroblasts during wound healing.

Poids moléculaire: 46638

UniProt: P43034

Pathways: M Phase, Regulation of Cell Size