UBASH3A anticorps (Internal Region)

N° du produit ABIN6257504

Détail du produit anti-UBASH3A anticorps

Antigène: UBASH3A (Ubiquitin Associated and SH3 Domain Containing, A (UBASH3A))

Épitope: Internal Region

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp UBASH3A est non-conjugé

Application: ELISA, Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificité: UBASH3A Antibody detects endogenous levels of total UBASH3A.

Homologie: Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human UBASH3A, corresponding to a region within the internal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur UBASH3A

Antigène: UBASH3A (Ubiquitin Associated and SH3 Domain Containing, A (UBASH3A))

Autre désignation: UBASH3A (UBASH3A Produits)

Synonymes: anticorps UBASH3A, anticorps CLIP4, anticorps STS-2, anticorps TULA, anticorps TULA-1, anticorps 5830413C03Rik, anticorps C330001M22, anticorps Sts-2, anticorps ubiquitin associated and SH3 domain containing A, anticorps ubiquitin associated and SH3 domain containing, A, anticorps UBASH3A, anticorps Ubash3a

Sujet:

Description: Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors, EGFR and PDGFRB, on the cell surface. Exhibits negligigle protein tyrosine phosphatase activity at neutral  pH . May act as a dominant-negative regulator of UBASH3B-dependent dephosphorylation. May inhibit dynamin-dependent endocytic pathways by functionally sequestering dynamin via its SH3 domain.

Gene: UBASH3A

Poids moléculaire: 74 kDa

ID gène: 53347

UniProt: P57075