PIP5K1C anticorps (Internal Region)

N° du produit ABIN6258304

Détail du produit anti-PIP5K1C anticorps

Antigène: PIP5K1C (Phosphatidylinositol-4-Phosphate 5-Kinase, Type I, gamma (PIP5K1C))

Épitope: Internal Region

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PIP5K1C est non-conjugé

Application: Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF)

Specificité: PIP5K1C Antibody detects endogenous levels of total PIP5K1C.

Homologie: Pig,Bovine,Sheep,Dog,Chicken

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human PIP5K1C, corresponding to a region within the internal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur PIP5K1C

Antigène: PIP5K1C (Phosphatidylinositol-4-Phosphate 5-Kinase, Type I, gamma (PIP5K1C))

Autre désignation: PIP5K1C (PIP5K1C Produits)

Synonymes: anticorps LCCS3, anticorps PIP5K-GAMMA, anticorps PIP5Kgamma, anticorps PIPKIg_v4, anticorps MGC130766, anticorps PIP5K1C, anticorps AI115456, anticorps AI835305, anticorps Pip5kIgamma, anticorps phosphatidylinositol-4-phosphate 5-kinase type 1 gamma, anticorps phosphatidylinositol-4-phosphate 5-kinase, type I, gamma S homeolog, anticorps phosphatidylinositol-4-phosphate 5-kinase, type I, gamma, anticorps phosphatidylinositol-4-phosphate 5-kinase, type 1 gamma, anticorps PIP5K1C, anticorps Pip5k1c, anticorps pip5k1c.S, anticorps pip5k1c

Sujet:

Description: Catalyzes the phosphorylation of phosphatidylinositol 4-phosphate (PtdIns4P) to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). PtdIns(4,5)P2 is involved in a variety of cellular processes and is the substrate to form phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3), another second messenger. The majority of PtdIns(4,5)P2 is thought to occur via type I phosphatidylinositol 4-phosphate 5-kinases given the abundance of PtdIns4P. Participates in a variety of cellular processes such as vesicle mediated transport, cell adhesion, cell polarization and cell migration. Together with PIP5K1A is required for phagocytosis, but they regulate different types of actin remodeling at sequential steps. Promotes particle attachment by generating the pool of PtdIns(4,5)P2 that induces controlled actin depolymerization to facilitate Fc-gamma-R clustering. Mediates RAC1-dependent reorganization of actin filaments. Required for synaptic vesicle transport. Controls the plasma membrane pool of PtdIns(4,5)P2 implicated in synaptic vesicle endocytosis and exocytosis. Plays a role in endocytosis mediated by clathrin and AP-2 (adaptor protein complex 2). Required for clathrin-coated pits assembly at the synapse. Participates in cell junction assembly. Modulates adherens junctions formation by facilitating CDH1 trafficking. Required for focal adhesion dynamics. Modulates the targeting of talins (TLN1 and TLN2) to the plasma membrane and their efficient assembly into focal adhesions. Regulates the interaction between talins (TLN1 and TLN2) and beta-integrins. Required for uropodium formation and retraction of the cell rear during directed migration. Has a role in growth factor- stimulated directional cell migration and adhesion. Required for talin assembly into nascent adhesions forming at the leading edge toward the direction of the growth factor. Negative regulator of T-cell activation and adhesion. Negatively regulates integrin alpha-L/beta-2 (LFA-1) polarization and adhesion induced by T-cell receptor. Together with PIP5K1A has a role during embryogenesis and together with PIP5K1B may have a role immediately after birth.

Gene: PIP5K1C

Poids moléculaire: 80 kDa

ID gène: 23396

UniProt: O60331

Pathways: Signalisation PI3K-Akt, Inositol Metabolic Process, Cell-Cell Junction Organization, Maintenance of Protein Location, Synaptic Vesicle Exocytosis