ITPK1 anticorps (Internal Region)
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- Antigène Voir toutes ITPK1 Anticorps
- ITPK1 (Inositol-Tetrakisphosphate 1-Kinase (ITPK1))
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Épitope
- Internal Region
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Reactivité
- Humain, Souris
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp ITPK1 est non-conjugé
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Application
- Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)
- Specificité
- ITPK1 Antibody detects endogenous levels of total ITPK1.
- Homologie
- Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus
- Purification
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogène
- A synthesized peptide derived from human ITPK1, corresponding to a region within the internal amino acids.
- Isotype
- IgG
- Top Product
- Discover our top product ITPK1 Anticorps primaire
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- Indications d'application
- WB 1:500-1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20 °C. Stable for 12 months from date of receipt.
- Date de péremption
- 12 months
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- Antigène
- ITPK1 (Inositol-Tetrakisphosphate 1-Kinase (ITPK1))
- Autre désignation
- ITPK1 (ITPK1 Produits)
- Synonymes
- anticorps ITRPK1, anticorps BC031182, anticorps wu:fj15d08, anticorps zgc:56075, anticorps inositol-tetrakisphosphate 1-kinase, anticorps inositol 1,3,4-triphosphate 5/6 kinase, anticorps inositol-tetrakisphosphate 1-kinase L homeolog, anticorps inositol-tetrakisphosphate 1-kinase a, anticorps ITPK1, anticorps Itpk1, anticorps itpk1.L, anticorps itpk1a
- Sujet
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Description: Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3. Phosphorylates Ins(3,4,5,6)P4 at position 1 to form Ins(1,3,4,5,6)P5. This reaction is thought to have regulatory importance, since Ins(3,4,5,6)P4 is an inhibitor of plasma membrane Ca2+-activated Cl- channels, while Ins(1,3,4,5,6)P5 is not. Also phosphorylates Ins(1,3,4)P3 on O-5 and O-6 to form Ins(1,3,4,6)P4, an essential molecule in the hexakisphosphate (InsP6) pathway. Also acts as an inositol polyphosphate phosphatase that dephosphorylate Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 to Ins(1,3,4)P3, and Ins(1,3,4,5,6)P5 to Ins(3,4,5,6)P4. May also act as an isomerase that interconverts the inositol tetrakisphosphate isomers Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 in the presence of ADP and magnesium. Probably acts as the rate-limiting enzyme of the InsP6 pathway. Modifies TNF-alpha-induced apoptosis by interfering with the activation of TNFRSF1A-associated death domain.
Gene: ITPK1
- Poids moléculaire
- 50 kDa
- ID gène
- 3705
- UniProt
- Q13572
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